摘要
目的:系统介绍来氟米特的作用机制、药代动力学、生殖毒性研究情况及其在育龄人群中的合理应用,希望可以为临床提供有益的参考。方法:查阅国内外相关文献,并对其进行分析、综合。结果:来氟米特禁用于妊娠期妇女及未采取可靠避孕措施的育龄妇女,若应用来氟米特的患者有妊娠计划,应停药,并采取帮助药物消除的措施。结论:来氟米特在育龄人群中的应用须慎重,有必要加强相关药学服务。
OBJECTIVE：To systematically introduce the mechanism of action,pharmacokinetics,reproductive toxicity of leflunomide and its rational application in population of childbearing age in an effort to provide beneficial clinical information.METHODS： We reviewed and meta-analyzed the pertinent literature both at home and abroad.RESULTS： Leflunomide is contraindicated in pregnant women or in women of childbearing age in whom no reliable contraception measure was taken.If leflunomide receivers have pregnancy plan,leflunomide must be withdrawn meanwhile measures should be taken to facilitate drug elimination.CONCLUSION： Leflunomide should be cautiously used in population of childbearing age,and it is necessary to strenghten the related pharmaceutical care.
出处
《中国医院用药评价与分析》
2010年第12期1060-1061,共2页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
来氟米特
育龄人群
合理应用
药学服务
Leflunomide
Population of childbearing age
Rational use
Pharmaceutical care
