摘要
将甲氧甲基引入β-环糊精的2,3,6-位合成了新的气相色谱手性固定相七(2,3,6-三-O-甲氧甲基)-β-环糊精,并采用静态法将其涂渍在毛细管内壁制备毛细管气相色谱柱。考察了毛细管柱的柱性能和分离性能。结果表明该固定相对Grob试剂、苯的二取代位置异构体(硝基甲苯、溴甲苯、二氯苯和二甲苯)及手性化合物(2-羟基丙酸甲酯、2-羟基丙酸乙酯和2-甲磺酰基丙酸甲酯)都具有良好的分离效果。与固定相2,3,6-三-O-甲基-β-环糊精的手性分离效果对比,结果显示两种手性固定相的分离能力各异,对一些手性脂类化合物对映体的分离存在互补性。
A new chiral stationary phase for gas chromatography,heptakis（2,3,6-tri-O-methoxymethyl）-β-cyclodextrin,was synthesized by substituting the 2,3,6-OH groups of β-cyclodextrin with methoxymethyl groups,and a coated capillary column for gas chromatography was made by coating this new stationary phase with static method.The chromatographic properties and separation abilities of the prepared stationary phase were studied.The test results showed that it possessed good separation abilities to Grob test mixture,disubstituted benzene isomers（e.g.nitrotoluenes,bromotoluenes,dichlorobenzenes,dimethylbenzenes） and some chiral compounds such as methyl 2-hydroxypropionates,ethyl 2-hydroxypropionates,methyl 2-methylsulfonylpropionates.The comparison of chiral separation results between 2,3,6-tri-O-methoxymethylβ-cyclodextrin and 2,3,6-tri-O-methyl-β-cyclodextrin showed that the separation abilities of the two stationary phases were different and complementary to each other for some chiral ester enantiomers.
出处
《色谱》
CAS
CSCD
北大核心
2011年第1期91-94,共4页
Chinese Journal of Chromatography
关键词
环糊精衍生物
固定相
毛细管气相色谱
位置异构体
手性化合物
cyclodextrin derivatives
stationary phase
capillary gas chromatography（CGC）
positional isomers
chiral compounds
