摘要
目的研究７０３－Ⅱ注射液对肠系膜微循环的作用。方法采用活体肠系膜微循环观察方法，结合血液粘度测量，共观察了氢溴酸樟柳碱、７０３－Ⅱ注射液、盐酸奴夫卡因三种药物对肠系膜微循环的影响。实验用大鼠按常规方法麻醉，然后以静脉注射给药，分别于药后１、５、１５、３０、６０、１２０ｍｉｎ在显微镜下观察大鼠肠系膜微血管管径、血流速度、流态等的变化。结果发现给药后３０～１２０ｍｉｎ，樟柳碱对肠系膜微动脉有一定扩张作用，而７０３－Ⅱ注射液对血管管径的作用不明显。奴夫卡因给药后１ｍｉｎ对肠系膜微动、静脉有一过性的收缩，而后舒张，血流减慢。注射生理盐水对血管管径及血流状态无明显改变。血液粘度测定显示樟柳碱、奴夫卡因对血液粘度改变不明显。结论７０３－Ⅱ注射液有显著降低血液粘度的作用。
Objective The effect of 703-Ⅱ injection contained Anisodine Hydrobromide,and the other two drugs,Novocane and Vitamine B_(12),on microcirculation of mesentery was studied. Microcirculation observation in vivo and blood viscosity were measured. Methods The animal was anesthetized intraperitoneally with Urethanum. The abdomen was opened via a midline incision of 20-30mm long. The mesentery was gently drawn out. The diameter of artery and venule,velocity of blood flow and flow state were observed after administering drugs through an inverted microscope in 5、15、30、60 and 120 minutes respectively.Results The results showed that the artery and the venue were extended by Anisodine after administration of drugs. The diameter of artery and venue didn't expand but the viscosity was changed with 703-Ⅱ Injection. Administration of drugs Anisodine and Novocain have no action in changing the viscosity.Conclusion 703-Ⅱ Injection has the effect of decreasing blood viscosity significantly.
出处
《中国微循环》
1999年第3期139-141,共3页
Journal of Chinese Microcirculation
