摘要
目的:观察奥沙利铂(L-OHP)联合亚叶酸钙(CF)和氟尿嘧啶(5-FU)方案治疗晚期结肠癌的近期疗效及安全性。方法:经病理组织学诊断的晚期结肠癌50例,随机分为治疗组30例,给予L-OHP+CF+5-FU治疗;对照组20例,给予卡铂+CF+5-FU治疗。21d为1个周期。2个周期评价疗效。结果:治疗组总有效率为50.00%,对照组总有效率为35.00%,2组比较差异有统计学意义(P<0.05);治疗组出现恶心呕吐、骨髓抑制患者少于对照组(P<0.05),但出现神经毒性、手足综合征的患者明显多于对照组(P<0.05)。结论:L-OHP联合CF和5-FU方案治疗晚期结肠癌的近期客观疗效较高,但远期疗效仍需进一步观察;不良反应主要是末梢神经毒性和胃肠道反应。
OBJECTIVE：To evaluate the therapeutic effect and toxicity of oxaliplatin plus 5-FU/CF in the treatment of advanced colorectal cancer.METHODS：50 patients with advanced colorectal cancer were randomly divided into 2 groups,control group 30 patients received L-OHP plus 5-FU/CF.20 cases in the control group received cisplatin plus 5-FU/CF.This regimen was repeated every 21 days.RESULTS：In the treatment group,the total effective rate was 50.00% in the control group,the total effective rate was 35.00%,the difference was statistically significant（P〈0.05）,adverse reactions was significant difference between the 2 groups（P〈0.05）.CONCLUSION：The combination of oxaliplatin and 5-FU/CF is an effective and tolerable regimen for treatment of advanced colorectal cancer.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第4期331-332,共2页
China Pharmacy
关键词
奥沙利铂
晚期结肠癌
近期疗效
安全性
Oxaliplatin
Advanced colorectal cancer
Short-term effect
Safety
