摘要
目的探讨荆州市医院感染大肠埃希菌(ECO)的感染现状和耐药性,为临床医师治疗感染性疾病提供科学依据。方法细菌分离培养严格按照《全国临床检验操作规程》,采用常规方法进行;菌株鉴定采用法国梅里埃VITEK-32全自动微生物分析仪操作;药敏试验采用K-B法。结果 375株大肠埃希菌对常用抗菌药物均产生了一定的耐药性;其中对氨苄西林耐药率最高,达81.6%;耐药率>50.0%的抗菌药物有头孢唑林、头孢呋辛、环丙沙星、磺胺甲噁唑/甲氧苄啶;对亚胺培南敏感率为100.0%;敏感率>60%的抗菌药物有阿莫西林/克拉维酸、头孢噻肟、头孢他啶、头孢吡肟、头孢西丁、头孢哌酮/舒巴坦、哌拉西林/他唑巴坦、氨曲南。结论医院应加强合理使用抗菌药物管理,严格控制耐药菌的产生和流行。
OBJECTIVE To approach the infection status and drug-resistance in nosocomial infections with Escherichia coli（ECO） in Jingshan and provide the scientific evidence for the clinical treatment of infective diseases.METHODS According to the National Guide to Clinical Laboratory Procedures,ECO were isolated and cultured by routine methods.The VITEK 32 system was used to identify the strains.Drug susceptibility testing was performed by K-B methods.RESULTS The drug resistance to commonly used antibiotics occurred in 375 isolates of ECO.The drug-resistant rate to ampicillin（81.6%） was the most highest.The antibiotics with above 50.0% drug-resistant rate were cefazolin,cefuroxime,ciprofloxacine and trimethoprim-sulfamethoxazole.There was no strain resistant to imipenem.The antibiotics with above 60.0% sensitivity rate were amoxicillin/clavulanat,cefotaxime,ceftazidime,cefepime,cefoxitin,cefoperazone/sulbactam,piperacillin/tazobactam and aztreonam.CONCLUSION The management of antibiotic application should be strengthened,the occurrence and prevalence of drug resistant bacteria should be strictly controlled.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第2期369-370,共2页
Chinese Journal of Nosocomiology
关键词
荆州市
医院感染
大肠埃希菌
耐药性
Jingzhou
Nosocomial infections
Escherichia coli
Drug resistance
