摘要
目的了解武汉地区肺炎链球菌对常用抗菌药物的耐药性及血清型分布。方法琼脂稀释法测定152株肺炎链球菌对15种抗菌药物最低抑菌浓度,荚膜肿胀试验进行血清学分型。结果152株肺炎链球菌中,耐青霉素肺炎链球菌(PRSP,MIC≥0.12 mg/L)的发生率为42.76%;第一、二、三代头孢菌素的耐药率依次降低,分别为94.08%、50.66%、41.45%和11.18%;红霉素、四环素、复方新诺明和氯霉素耐药率分别为84.21%、88.82%、89.47%和18.42%;新喹诺酮类左氧氟沙星和莫西沙星的耐药率均为1.32%;血清分型共涉及20个血清型、群,主要集中在19、23、6、15和14血清群,PRSP分布在6、19、23和未分型血清群。结论武汉地区肺炎链球菌耐药性高,应注意合理选择用药;血清分型,尤其多重耐药株以6、19和23血清群为主,推荐疫苗免疫预防肺炎链球菌感染。
OBJECTIVE To investigate antibiotic resistance and the prevalence of serotype of Streptococcus pneumoniae in Wuhan. METHODS Totally 152 strains of S. pneumoniae were collected to test the MICs of various antibiotics by agar dilution method according to the approved standard of NCCLS. Serotyping of S. pneumoniae was performed by using quelling reaction. RESULTS Among 152 strains of S. pneumoniae, 65 （42.76%） strains were resistant to penieillin（MIC≥0.12mg/L）. 94. 08%, 50. 66%, 41.45% and 11.18% of S. pneumoniae were resistant against the first （eefalexin）,second （eefaelor） and third （eefaxime and eeftriaxone） generation of cephalosporins respectively. The resistance rates to other antibiotic agents, such as erythromycin, tetracycline, trimethoprim/sulfamethoxazole and ehloramphenieol, were 84.21%, 88.82 %, 89.47 % and 18.42 %, respectively. Strains that were resistant to levofloxacin and moxifloxacin were found both for 1.32%. Twenty serotypes were involved in 152 strains. The prevalent serotypes were 19（25.66%）,23（19.08%）,6（13.82%）, 15 （7. 24%） and 14 （4. 61%）. Eight strains were remained for unable to serotype. All penicillin-resistant S. pneumoniae was included in serotypes 6,19 and 23. CONCLUSIONS The antibiotic resistance of S. pneumoniae is serious in Wuhan. Most of them are multi-resistant strains. Except for fluoroquinolones, eeftriaxone and cblorampbenicol, most antibiotic agents have lost there activities against S. pneumoniae. The prevalent serotypes, especially of the multi-resistant strains, were 19,23 and 6. Pneumoeoeeal polyvalent vaccine can well cover these serotypes.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2007年第4期468-471,共4页
Chinese Journal of Nosocomiology
关键词
肺炎链球菌
耐药性
血清分型
Streptococcus pneumoniae
Resistance
Serotype
