摘要
目的:观察益气健脾法联合化疗对大肠癌术后脾虚证患者的疗效。方法:将60例符合入选标准的大肠癌患者,随机分为单纯化疗组(20例);化疗加健脾组(20例);化疗加柘木组(20例);3组疗程为42天。治疗结束后评价疗效,观察3组患者治疗前后中医症状积分和疗效变化、生存质量、免疫功能、毒副反应等方面的变化。结果:①3组中医症状比较,化疗加健脾组治疗后脾虚症状积分明显低于治疗前,有显著差异(P<0.05),与单纯化疗组比较,有显著差异(P<0.01),与化疗加柘木组比较,差异无显著性(P>0.05);化疗加健脾组中医总有效率优于单纯化疗组与化疗加柘木组,差异有显著性(P<0.05);②3组卡氏评分比较,化疗加健脾组、化疗加柘木组较治疗前有明显提高,有显著差异(P<0.05),而单纯化疗组略有降低(P>0.05),治疗后组间卡氏评分比较,化疗加健脾组高于化疗与化疗加柘木组,有非常显著差异(P<0.01);③化疗加健脾组治疗后NK细胞活性及CD4/CD8比值均有提高,与治疗前相比有显著差异(P<0.05),与单组间比较有显著差异(P<0.05);与化疗加柘木组比较,治疗后NK细胞活性,差异无显著性(P>0.05),CD3、CD4/CD8差异有显著性(P<0.05)。结论:化疗结合益气健脾法治疗大肠癌,能够增强化疗的近期疗效,减少部分毒副反应,有效改善大肠癌术后患者脾虚症状,提高生活质量,改善病人免疫状态,起到减毒增效作用。
Objective：To observe and compare the therapeutic effect of Jianpi Yiqi methods combined with chemotherapy in treating post-operational colorectal cancer patients with spleen qi deficiency Syndrome.Methods： Adopting randomized control trial method,60 patients were divided into three groups.The treatment group（chemotherapy plus traditional Chinese medicine,n=20）,control group1（chemotherapy plus tsugeki syrup n=20） and control group 2（chemotherapy only,n=20）.A treatment course of 42 days was applied to all groups,the therapeutic effect,change of spleen qi deficiency Syndrome,life quality and immune effect and adverse reaction were observed.Results： ①in the aspect of TCM symptom control,after treatment,the score of TCM spleen qi deficiency in the treatment group descended,the difference had statistically significance（P〈0.05）,While the score in control group 2 increased.Compared with control group 1 and 2,TCM symptom control in the treatment group is superior,the difference had statistically significance（P〈0.05）.②in the aspect of KPS score,after treatment,the KPS score of treatment group and control group1 was obviously enhanced,the difference was statistically significant（P〈0.05）,the KPS score of control group 2 was reduced,After treatment,the KPS score in treatment group is higher than that in control group 1 and 2,the difference in those three groups was statistically significant（P〈0.01）.③There was a significant enhancement of NK cell activity and ratio of CD4/CD8 in treatment group（P〈0.05）,While the result for control group 2 was contrast,there was a little drop（P〈0.05）,the difference between two groups was statistically significant（P〉0.05）.After treatment,the difference of the change of NK cell between treatment group and group 1 was not obvious（P〉0.05）,while the difference of CD3 and ratio of CD4/CD8 between two groups had statistically significant（P〈0.05）.Conclusions： In the therapy of post-operational colorectal cancer patients wit
出处
《中华中医药学刊》
CAS
2011年第1期154-156,共3页
Chinese Archives of Traditional Chinese Medicine
基金
慈溪市科技计划项目(CN2008020)
关键词
化疗
益气健脾法
大肠癌
免疫功能
临床研究
chemotherapy
Jianpi Yiqi methods
colorectal cancer
immunity function
clinic research
