摘要
目的观察胃乐散对急性化脓性梗阻性胆管炎大鼠肝脏的保护作用。方法不完全结扎胆总管制备大鼠急性化脓性梗阻性胆管炎模型,胃乐散灌胃给药72 h后,取血和肝脏组织标本,检测血胆红素水平、肝脏功能,观察肝脏组织病理学变化。结果与假手术组相比,模型组大鼠血总胆红素水平均显著升高,ALT和AST水平也明显升高;与模型组相比,0.2 g/kg胃乐散显著降低血总胆红素、ALT和AST水平,但高于假手术组水平。病理组织学检查发现,模型组肝脏肿大淤血,表面有较多散在脓苔,镜下观察到肝细胞排列紊乱,出现大面积的水肿、变性、坏死,胃乐散给药组肝组织损伤明显减轻。结论胃乐散对急性化脓性梗阻性胆管炎大鼠肝脏损伤具有明显保护作用。
Objective To observe the liver protection of wei-le-san in acute obstructive suppurative cholangitis.Methods The acute obstructive suppurative cholangitis model of wistar rat was prepared by incompletely ligating biliary tract.After wei-le-san were administrated 72 hours by intragastric administration,blood samples were collected for the level of bilirubin,hepatic function.histopathological examine.Histopathological changes of liver and bile duct tissues were observed through naked eye and light-microscope.Results The level of TBIL,ALT and AST all were increased in model group compared with sham operated group（P〈0.05,P〈0.01）.The level TBIL,ALT and AST in serum were decreased after treatment with wei-le-san 0.2 g/kg,but were higher than sham operated group（P〈0.05）.Wei-le-san treatment could significantly reduce the histopathological damage,such as liver intumesce,hepatocyte necrosis and pus music were decreased compared with liver tissue of acute obstructive suppurative cholangitis rat.Conclusion Wei-Le-san can significantly protect liver function and tissue morphous in acute obstructive suppurative cholangitis rat.
出处
《重庆医学》
CAS
CSCD
北大核心
2011年第1期1-2,6,F0003,共4页
Chongqing medicine
基金
遵义市科技局资助课题[遵市科合社字2009(11)]
关键词
胆管炎
肝功能试验
胆红素
肝脏
胃乐散
cholangitis
liver function tests
bilirubin
liver
wei-le-san
