摘要
目的:动态观察蒙药清肝二十七味丸对不同病变阶段慢性肝损伤小鼠的保肝作用,为临床合理用药提供依据.方法:将小鼠随机分为正常对照组、模型组、乙肝宁颗粒组、清肝二十七味丸高、低剂量组.除正常对照组外,其余小鼠均腹腔注射DMN致慢性肝损伤,造模同时清肝二十七味丸高、低剂量、乙肝宁颗粒组分别灌胃清肝二十七味丸和乙肝宁颗粒每日1.67g/kg、1g/kg和1g/kg.于第5、7次注射二甲基亚硝胺(DMN)后观察肝组织病理学的变化.结果:第5、7次注射DMN后慢性肝炎炎症活动度分级(G)和慢性肝炎程度(G/S)比较模型组处于逐渐加重趋势,主要表现为中、重度病变状态;清肝二十七味丸处于轻、中度病变状态.结论:清肝二十七味丸对轻、中程度的慢性肝损伤有更好的保肝作用,建议临床上应随着病情变化给予合理的辨证用药.
Objective：To observe the protective effect of Mongolian medicine Qinggan-27 pill on different pathological stages of chronic hepatic injury in mice,to provide a basis for clinical use of drugs.Methods： The mice were randomly divided into normal control group,model group,Yiganning particles group,Qinggan-27 pill high and low dose groups.Except the normal control group,other mice were caused chronic hepatic injury by intraperitoneal injection of dimethylnitrosamine（DMN）,at the same time,the mice in Qinggan-27 pill high and low dose groups,Yiganning particles group were given intragastric administration Qinggan-27 pill and Yiganning particles with 1.67g/kg,1g/kg and 1g/kg each day.After the fifth and seventh injection of DMN,observing the pathological changes of liver tissue.Result：The grading of inflammatory activity of chronic hepatitis（G）and the degree of chronic hepatitis（G/S）in model group had gradually increasing trend and showed the moderate and severe disease status;Qinggan-27 pill groups were in the mild and moderate disease status.Conclusion： Qinggan-27 pill has a better protective effect on mild and moderate chronic hepatic injury,and we propose that reasonable diagnosis and prescription should be given along with changes of clinical condition.
出处
《内蒙古民族大学学报（自然科学版）》
2010年第6期671-674,共4页
Journal of Inner Mongolia Minzu University：Natural Sciences
基金
内蒙古自治区卫生厅"蒙药复方标准化研究"专项基金项目(2010001)
关键词
蒙药清肝二十七味丸
慢性肝损伤
组织病理
Mongolian medicine Qinggan-27 pill
Chronic hepatic injury
Pathology
