摘要
以3,4-二甲氧基苯乙酸和3,4,5-三甲氧基苯酚为原料,通过一条包括酯化反应、Fries重排、以及Vilsmeier-Haack反应等5步反应的路线合成了天然产物5,6,7,3′,4′-五甲氧基异黄酮。根据3,4,5-三甲氧基苯酚计算目标产物的总收率为76%,利用NMR及元素分析确证了化合物的结构。
The natural product 5,6,7,3＇,4＇-pentamethoxyisoflavone was synthesized by a 5-step synthetic protocol including esterification,Fries transformation,and Vilsmeier-Haack reaction with 3,4-dimethoxyphenylacetic acid and 3,4,5-trimethoxyphenol as the starting materials.The overall yield of the target compound was 76% based on 3,4,5-trimethoxyphenol.The structure of the natural isoflavone 5,6,7,3＇,4＇-pentamethoxyisoflavone was confirmed by NMR and elemental analysis.
出处
《天然产物研究与开发》
CAS
CSCD
2010年第6期956-960,共5页
Natural Product Research and Development
基金
supported by Program for Changjiang Scholars and Innovative Research Team in University(No.IRT0526)
Shanghai Natural Science Foundation(No.06ZR14001)
