摘要
目的研究慢性脑供血不足(CCCI)患者脑血流动力学变化及其颈动脉粥样硬化特点。方法分别对50例CCCI患者(CCCI组)和50例正常对照者(正常对照组)及50例脑梗死患者(脑梗死对照组)行颈动脉彩色多普勒及经颅多普勒检查,并测量相关指标。结果 CCCI组颈动脉粥样斑块发生率为52.0%(26/50),颈动脉内膜中层厚度>1.00 mm者占24.0%(12/50),颈动脉狭窄率为22.0%(11/50),颅内血流异常率为60.0%(24/40),颅内血管狭窄率为20.0%(8/40),而正常对照组分别为14.0%(7/50),4.0%(2/50),4.0%(2/50),16.7%(5/30),3.3%(1/30);脑梗死对照组分别为82.0%(41/50),68.0%(34/50),48.0%(24/50),92.6%(25/27),51.9%(14/27),CCCI组与正常对照组比较差异有统计学意义(P<0.01),脑梗死对照组与CCCI组比较差异亦有统计学意义(P<0.01)。CCCI组颈动脉彩色超声检查的斑块、不稳定斑块I、MT增厚和颈动脉狭窄发生率及TCD检查的血流速度异常率、RI、PI等介于正常对照组与脑梗死对照组之间。结论 CCCI是动脉粥样硬化过程的一个阶段,是脑梗死的预兆。CCCI是血栓前状态,是脑梗死的后备军,斑块的不稳定性是急性脑梗死重要危险因素。
Objective To study the characters of cerebral blood flow and atherosclerosis in the patients with chronic cerebral circulation insufficiency（CCCI）.Methods Fifty patients diagnosed as CCCI were assigned in test group,while 50 healthy subjects and 50 cerebral infarction cases served as two control groups.Each case was given carotid color Doppler examination and TCD to measure related indexes.Results In the test group,incidence of carotid atherosclerosis plaque,carotid intimal medial thickness（IMT） 1.0 mm,carotid stenosis,abnormal intracranial artery blood flow,and intracranial vascular stenosis were 52.0%,24.0%,22.0%,60.0%,20.0% respectively.In the normal control group,the related data were 14.0%,4.0%,4.0%,16.7%,and 3.3%,respectively.And in the infarction control group,they were 82.0%,68.0%,48.0%,92.6% and 51.9%,respectively.There were significant difference both between the test group and the normal control group（P〈0.01）,and between the test group and the infarction control group（P〈0.01）.Both incidence of plaque,unstable plaque,thickened IMT,carotid stenosis and incidence of abnormal blood speed in TCD,RI,PI in CCCI group were between the normal control group and the infarction control group,thus indicating that CCCI is a transition stage during the development of atherosclerosis.Conclusion CCCI is a transition stage during the development of atherosclerosis,which we know as a prothrombotic state,and also it is a predictor as well as reserve force of ischemic stroke.Especially the plaque instability is an important risk factor for acute cerebral infarction.
出处
《临床荟萃》
CAS
2011年第2期117-120,共4页
Clinical Focus
关键词
脑缺血
脑梗塞
颈动脉疾病
超声检查
多普勒
经颅
brain ischemia
brain infarction
carotid artery diseases
ultrasonography
Doppler
transcranial
