摘要
目的:探讨阿卡波糖对糖耐量异常(IGT)患者干预的临床疗效。方法:将我院门诊糖耐量异常患者106例随机分为两组,治疗组56例,在生活方式干预基础上给予阿卡波糖片50 mg,po,tid;对照组50例,仅给予生活方式干预。观察期间均进行糖尿病防治知识宣教,根据个体情况制定饮食及运动方案,观察12个月。结果:两组体重指数、血压、空腹血糖、葡萄糖负荷后2 h血糖、糖化血红蛋白、血脂等指标明显变化,治疗前、后差异均有统计性意义(P<0.01或<0.05)。治疗组糖尿病发生率为9.1%,明显低于对照组糖尿病发生率28%(P<0.05)。结论:阿卡波糖治疗IGT可明显降低糖尿病发生。
Objective： To investigate the intervention effect of acarbose on the subjects with impaired glucose tolerance （IGT）. Method： 106 cases of IGT received conventional education on diabetes prevention and underwent an individually designed diet and ex-ercise program. The cases were divided into two groups ： the experimental group, orally given acarbose 50 mg tid, and the control group given no drugs. The observation duration was 12 months. Result： The levels of body mass index （ BMI）, blood pressure （ BP）, fasting plasma glucose （FPG） ,2 h oral glucose-tolerance test （2 hOGTT）, hemoglobin A1 c （HbA1 c） and blood fat in the two groups were both decreased significantly （ P 〈 0. 01 and P 〈 0. 05, respectively） after intervention. The annual diabetes incidence of the experimental group was 9. 1% which had significant difference （P 〈 0. 05 ） from that of the control group （28%）. Conclusion： The pharmacological interventions with Aacarbose could significantly decrease diabetes incidence of IGT population.
出处
《中国药师》
CAS
2011年第1期106-107,共2页
China Pharmacist
关键词
阿卡波糖
糖耐量异常
糖尿病
Acarbose
Impaired glucose tolerance
Diabetes mellitus
