摘要
选用硬脂酸、单硬脂酸甘油酯混合脂质作为载体,以卵磷脂作为乳化剂制备黄芩苷固体脂质纳米粒(BC-SLN),并考察其大鼠在体肠吸收特性.采用热匀质法(hot homogenization technique,HHT)制备BC-SLN,采用循环灌注技术评价黄芩苷固体脂质纳米粒和黄芩苷溶液大鼠在体肠吸收特性.制得的BC-SLN平均粒径为(150.8±47.2)nm,zeta电位为(-39.85±0.86)mV,载药量为(4.86±0.37)%,包封率为(88.52±0.32)%,大鼠在体肠吸收实验表明,BC-SLN与黄芩苷溶液相比,吸收速率常数Ka和每小时吸收百分率p均呈增加趋势,有显著性差异(P<0.05),黄芩苷固体脂质纳米粒能够促进黄芩苷大鼠肠吸收.
Baicalin solid lipid nanoparticles（BC-SLN） are prepared with a mixture of stearic acid and monostearin by hot homogenization technique.The mean diameter of BC-SLN is（150.8±47.2） nm.The zeta potential of BC-SLN is（-39.85±0.86） mV.The drug loading and entrapment efficiency are（4.86±0.37）% and（88.52±0.32）%,respectively.The absorption parameters of BC-SLN and baicalin solution in rat intestines are characterized by using recirculating perfusion technique.The Ka and p of BC-SLN in rat intestines are remarkably higher than those of the baicalin solution（P0.05）.The absorption of BC-SLN in rat intestines is improved significantly compared with the reference baicalin solution.
出处
《烟台大学学报（自然科学与工程版）》
CAS
北大核心
2011年第1期54-58,共5页
Journal of Yantai University(Natural Science and Engineering Edition)
关键词
黄芩苷
固体脂质纳米粒
包封率
小肠吸收
baicalin
solid lipid nanoparticles
entrapment efficiency
intestinal absorption
