摘要
以L-鸟氨酸盐酸盐为原料与五水硫酸铜反应生成二鸟氨酸合铜保护α-NH2,用尿素对δ-NH2甲酰化得到二瓜氨酸合铜,后用二水合草酸脱α-NH2保护得到目标产物L-瓜氨酸,总收率49.5%。用同样的方法以L-赖氨酸盐酸盐为原料制备了L-高瓜氨酸,总收率53.5%。产物经IR、熔点、旋光确证。该方法具有操作方便、安全、经济和环保等特点。
A novel method for the synthesis of L-citrulline and L-homocitrulline was reported.In this process,L-ornithine monohydrochloride reacted with copper sulfate pentahydrate to protect α-NH2,and δ-NH2 was carbamylated with carbamide,then the copper ion was removed through the combination with oxalate dihydrate to give L-citrulline with an overall yield of 49.5%.L-homocitrulline was prepared from L-lysine monohydrochloride in the same method with an overall yield of 53.5%.The structure of the aimed compound was confirmed by IR,melting point and optical rotation.This synthetic route was convenient,safe,economical,and environmental friendly.
出处
《精细化工》
EI
CAS
CSCD
北大核心
2010年第12期1213-1215,共3页
Fine Chemicals
基金
江苏省自然科学基金资助项目(BK2009523)
江苏省高校自然科学基金资助项目(09KJB350003
08KJD530004)
徐州市科技计划项目(XM08C059)
徐州医学院肿瘤生物治疗实验室资助项目(C0903
C0904)
江苏省高等学校大学生实践创新训练计划项目(2008)~~
