摘要
目的 通过分析新疆乌鲁木齐地区汉族与维吾尔族女性骨质疏松患者骨代谢和血脂的水平,探讨血脂与骨质疏松症的关系。方法 选择2008年5月至2010年2月期间,我院就诊的女性骨质疏松患者134例,其中,汉族88例,维吾尔族46例,对比分析两组体重指数、血清电解质、部分骨生化标志物以及血脂水平。结果两组体重指数、血清Ca、P、Mg水平无统计学差异(P>0.05);骨特异性碱性磷酸酶(BAP)、骨钙素(BGP)水平,维族组高于汉族(P<0.05),抗酒石酸酸性磷酸酶5b(TRACP-5b)水平两组无显著性差异(P>0.05);高密度脂蛋白、总胆固醇、低密度脂蛋白、甘油三酯和载脂蛋白α,两组无明显统计学差异(P>0.05);高密度脂蛋白低于正常值的维族患者有6例,汉族有25例,两组具有统计学差异(P<0.05)。结论 通过影响成骨细胞的骨代谢水平,高密度脂蛋白异常可能是新疆乌鲁木齐地区汉族女性骨质疏松患者的危险因素之一。
Objective To explore the relationship between serum lipid level and osteoporosis by analyzing the bone metabolic and biochemical markers and lipid levels in Han and Uygur osteoporosis women in Urumqi of Xinjiang. Methods One hundred and thirty-four osteoporotic women diagnosised in our hospital from May 2108 to Feb 2010 were included in the study. Among those, 88 patients were Han and 46 were Uygur.nationality. The body mass index （BMI） , serum electrolytes, bone biochemical markers, and serum lipid levels of patients between the Han and Uygur group were analyzed and compared. Results There were no significant differences in BMI, serum Ca, P, and Mg levels between Han patients and Uygur patients. The levels of bone specific alkaline phosphase （BAP） and BGP in.Uygur patients were significantly higher than those in Han patients （ P 〈 0.05 ）. There were no significant statistical differences in TRACP-Sb between the two groups （P 〉 0.05）. There were also no significant statistical differences in levels of serum total cholesterol, low density lipoprotein, triglycerides, and apo-lipoprotein between the two groups （P 〉 0.05）. The levels of high density lipoprotein （HDL） in 6 Uygur patients and 25 Han patients were under the normal level. The statistical significance existed between the two groups （P 〈 0. 05）. Conclusion By influencing bone metabolic level of osteoblasts, HDL abnormality may be one of the osteoporosis risk factors for Han women.
出处
《中国骨质疏松杂志》
CAS
CSCD
2010年第11期813-816,共4页
Chinese Journal of Osteoporosis
关键词
骨质疏松
骨代谢生化指标
高密度脂蛋白胆固醇
Osteoporosis
Bone metabolic and biochemical markers
High-density lipoprotein cholesterol
