摘要
目的:观察小儿消食颗粒的促进消化作用及最大耐受量。方法:采用昆明种小鼠进行小肠运动实验,设置阴性对照组、复方地芬诺酯模型对照组和受试物低、中、高剂量组(分别为1,2,4 g.kg-1);采用SD大鼠设置阴性对照组和受试物低、中、高剂量组,进行体重、体重增重、进食量和食物利用率试验以及消化酶的测定试验,受试物连续ig 30 d;最大耐受量试验观察药物的急性毒性。结果:小儿消食颗粒对复方地芬诺酯负荷小鼠的小肠运动均有明显的促进作用;能够增加大鼠体重及食物利用率,还能明显提高大鼠胃蛋白酶活性并增加胃蛋白酶排出量;小儿消食颗粒小鼠的最大耐受量为儿童1日用量的54倍(56 g.kg-1)。结论:小儿消食颗粒有明显促进消化的作用,且常用剂量口服给药安全。
Objective：To observe the effects of Promoting Pedo-digestion Granules （PPD） on the digestion and absorption function and its maximum torerance dose （ MTD）. Method： The distance of ink moving in small intestine in KM mice was used to evaluate the effect. The mice were randomly divided into treatment groups, control groups and the difenoxin model control group. Treatment groups were fed with 1,2, 4 g· kg^-1 dosage accordingly. The body weight, food intakes, food efficiency ratio and the secretion amount of SD rats＇ gastric juice and pepsin activity were also used to evaluate the effect. The rats were randomly divided into treatment groups and control groups. Treatment groups were fed with dosage as the above. PPD were fed for 30 days. MTD was measured. Result：PPD could increase the rate of ink promoting, which was superior to that in the difenoxin model control group, PPD also could increase the body weight of rats, appetite and food exploitation rate, promote the secretion amount of gastric juice and pepsin, pepsin activity, which was superior to that in the control group. MTD was 56 g · kg^-1 as about 54 times of population recommended amount. Conclusion： PPD has the function of promoting the digestion and absorption function, and oral dose commonly used is safe.
出处
《中国实验方剂学杂志》
CAS
北大核心
2010年第18期132-134,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
南京中医药大学科技创新基金项目(CX200704)
关键词
小儿消食颗粒
小肠运动
胃蛋白酶
最大耐受量
Promoting Pedo-digestion Granules
intestine movement
pepsin
maximum torerance dose
