摘要
p53作为肿瘤致病的关键因子人们已经进行了广泛的研究,microRNA参与肿瘤的发生也已经成为了不争的事实,但目前关于p53与miRNA的调控关系还不是很清楚。就p53与miRNA存在的可能调控模式及p53对miRNA功能与合成方面的影响进行了综述,并结合已有的研究绘制了可能的p53与miRNA调控模式图。
As a key pathogenic factor in tumorigenesis,p53 had been researched widely.MicroRNA involved in the cancer disease also become a undisputed factor,but the relationship between p53 and microRNA regulation was unclear.Recent studies that shed light on p53 and miRNA possible regulation model and the action of p53 in miRNA function and synthesis were discussed.Finally,the schematic illustration of putative p53-microRNA regulatory pathway also was presented and discussed.
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2010年第11期79-82,共4页
China Biotechnology
基金
西南交通大学青年教师科研起步项目(2009Q051)
中央高校基本科研业务费专项资金(SWJTU09BR217
SWJTU09BR222
SWJTU09ZT28)资助项目
