摘要
目的探讨125I粒子近距离照射治疗对肿瘤位置邻近边缘和膈下的肝恶性肿瘤的治疗价值。方法对16例邻近边缘和膈下的肝恶性肿瘤患者进行125I粒子植入近距离放射治疗,所有患者术前均经过肝动脉栓塞化疗(TACE);合并肝内病灶的患者粒子植入术中联合射频消融治疗。结果粒子植入术后2个月以超声造影观察肿瘤微循环状况,24枚病灶未见增强者17枚,(71%),部分或边缘增强者7枚,(29%),未见整体快速强化;生存率随访6个月、1年分别为100%和72.5%。并发症主要是气胸、粒子迁徙等。结论 125I粒子近距离治疗在肿瘤位置邻近肝脏边缘和膈下这样的特殊位置的治疗中有独特的地位,值得临床推广。
Objective To evaluate the therapeutic effects of radioactive 125I seed brachytherapy for malignant hepatic tumors located at the marginal zone or close to the diaphragmatic fornix.Methods Brachytherapy with radioactive 125I seeds was performed in 16 patients of liver malignant lesions which were located at the marginal zone or close to the diaphragmatic fornix.Before brachytherapy all patients had received transcatheter arterial chemoembolization （TACE）.For patients with coexisting malignant lesions located at the central part of the liver radiofrequency ablation was simultaneously employed during brachytherapy procedure.Results Two months after the treatment contrast-enhanced ultrasound was performed to check the circulation status in tumor.Of the total 24 lesions,no enhancement was seen in 17 （71%） and partial or peripheral enhancement in 7 （29%）.No rapid enhancement of entire tumor was observed.The survival rate at 6 and 12 months after the treatment was 100% and 72.5%,respectively.The major complications included the pneumothorax and particle migration.Conclusion Brachytherapy with radioactive 125I seeds possesses unique effectiveness in treating malignant hepatic tumors located at the marginal zone or close to the diaphragmatic fornix.This technique should be highly recommended in clinical practice.
出处
《介入放射学杂志》
CSCD
北大核心
2010年第11期878-881,共4页
Journal of Interventional Radiology
