摘要
目的:研究妊娠期肝内胆汁淤积综合症(ICP)的产科处理及预防护理,探讨治疗对母婴预后的影响。方法:选取2009年1月至2010年1月第四军医大学西京医院妇产科收治ICP患者共67例,分为治疗组49例,经过丁烷二磺酸腺苷蛋氨酸(思美泰),对照组18例服用熊去氧胆酸治疗的孕妇。对孕妇症状、生化指标、母婴结局进行比较分析。结果:治疗组临床症状、生化指标较治疗前明显下降较对照组明显好转(p<0.01),直接胆红素下降两组间无显著差异(p>0.01)。将治疗组和对照组胎儿宫内窘迫率存在显著性差异(p<0.01)。结论:应用丁烷二磺酸腺苷蛋氨酸(思美泰)积极正确处理ICP,可明显减轻孕妇瘙痒症状及肝功异常,同时明显降低胎儿宫内窘迫率,提高围生儿的生存质量。
Objective：The aim of this study to compare the effect of treatment and nursing in patientts with intrahepatic cholesta-sis of pregnancy.Methods：Intrahepatic cholestasis of pregnancy is a rare disorder,predominately occurring during the third trimester of pregnancy.We performed a retrospective analysis enrolling 67 women with ICP deliveries at the Department of Obstetrics and Gynecology,Xijing Hospital between January 2009 and January 2010.The patients are divided into 2 groups,49 patients in the treatment group were treated with transmetil and 18 in control group were treated with ursodeoxycholic acid.Results：While intrahepatic cholestasis of pregnancy showed little maternal risk,there is significant risk to the fetus.For ICP patients treated with transmetil,their pruritus,jaundice,and biochemical disturbances in liver enzymes were reduced significantly,and meconium staining of non-reassuring fetal status were reduced significantly also.Conclusion：The more effective mothers were found for ICP mother and their children by treated with transmetil.Treatment with ursodeoxycholic acid is suggested,coupled with close maternal-fetal surveillance and delivery as close to term as possible.perinatal mortality.
出处
《现代生物医学进展》
CAS
2010年第22期4310-4312,共3页
Progress in Modern Biomedicine
