摘要
目的 探讨腺苷蛋氨酸（SAMe）联合低分子肝素（LMWH）治疗肝内胆汁淤积症（ICP）的临床效果及安全性. 方法 47例ICP患者在知情同意情况下按入院单双号随机分成A组21例和B组26例,两组均给予常规治疗,同时B组给予SAMe治疗,A组给予SAMe联合LMWH治疗,观察比较两组治疗前后肝功能、瘙痒评分、羊水粪染率、术中出血、Apgar评分及胎儿出生体质量等情况. 结果 两组患者治疗后血胆汁酸、丙氨酸转氨酶、天冬氨酸转氨酶、总胆红素等水平及瘙痒评分均较治疗前明显降低（均P＜0.01）,A组治疗后较B组下降更明显（均P＜0.05）.A组羊水Ⅲ度粪染率较B组低（P＜0.01）.两组分娩孕周、剖宫产率、分娩出血量、早产率、胎儿出生体质量及新生儿窒息率等比较,差异均元统计学意义（均P＞0.05）. 结论 SAMe联合LMWH治疗ICP优于常规单纯SAMe的治疗方法,近期使用安全有效.
Objective To investigate the efficacy of S-adenosy-L-methionine （SAMe） combided with LMWH in the treatment of intrahepatic cholestasis of pregnancy. Methods 47 patients with intrahepatic cholestasis of pregnancy were divided into two groups：A group（n = 21）received a combination of SAMe and LMWH,B group（n = 26）received only SAMe.The symptom of itching and serum biochemical indexes,including TBA,TB,ALT,and AST were observed after 7days,and the pregnancy outcome between the two groups were compared after delivery. Results All the patients had a significant improvement in pruritus and TBA,TB,ALT,and AST（P 〈0.01=.After 7 days,there were significant differences in prurits,FBA,AST,ALT,in receiving combination of SAMe and LMWH comparing with received SAMe alone（P 〈0.05=.The incidence of amniotic fluid pollution was significantly different between the two groups（P〈0.01=. Conclusion In women with intrahepatic cholestasis of pregnancy,combination of SAMe and LMWH were safe and efficient in the near future.
出处
《中国基层医药》
CAS
2010年第16期2181-2182,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
肝内胆汁淤积症
腺苷蛋氨酸
低分子肝素
Intrahepatic cholestasis
S-adenosy-L-methionine
Low molecular weight heparin
