摘要
为预测土霉素在鸡体内的药动学特点,建立了土霉素在鸡体内的血流限速生理房室模型。结果显示,土霉素在鸡体内的药动学参数:Tmax(达峰时间)为2.22h,Cmax(峰浓度)为0.62μg/mL,AUC(药时曲线下面积)为7.61(μg/mL)×h,Ka(吸收速率常数)为1.21h-1,Ke(消除速率常数)为0.10h-1,T1/2Ka(吸收半衰期)为0.57h,T1/2Ke(消除半衰期)为6.73h,V(表观分布容积)为6.38L/kg,CL(血浆清除率)为0.66L/h·kg。其结果表明,土霉素在鸡体内的药动学特点为:吸收迅速,分布广泛,消除缓慢。因此,运用生理房室模型可以预测药物的药动学参数。
To predict the pharmacokinetic charac, teristics of Oxytetracycline in chicken,a flow limited physiological compartment model for Oxytetracycline in chicken was developed. The pharmacokinetic parameters of Oxytetraeycline in chicken were as follows ： Tmax 2.22 h,Cmax 0.62 μg/mL,AUC 7.61（μg/mL）×h,K, 1.21 h^-1,Ke 0.10 h^-1,T1/2Ka 0.57 h,T1/2Ke 6.73 h, V 6.38 L/kg,CL 0.66 L/h·kg. The results indicated that the pharmacokinetic characteristics were absorbed rapidly, distributed widely and eliminated slowly. The drug pharmacokinetic parameters can be predicted by the physiological compartment model.
出处
《中国家禽》
北大核心
2010年第22期25-27,共3页
China Poultry
基金
中国博士后科学基金(20080440762)
关键词
土霉素
生理房室模型
鸡
药动学参数
Oxytetracycline
physiological compartment model
chicken
pharnlacokinetic parameters
