摘要
生理药动学模型是一种基于物质平衡原理而建立的整体模型,能够预测化学异物在动物体内的吸收、分布、代谢和排泄规律。在兽医领域,生理药动学模型主要用于研究兽药的药动学特征、预测兽药的组织分布及残留休药期。目前,有关生理药动学模型的研究多集中在猪、牛、山羊、绵羊及狗,家禽的相关研究较少。家禽的解剖学结构与哺乳动物相比,差异巨大,且禽蛋的成分及形成过程均极其复杂,因此较难利用生理药动学模型预测家禽可食性组织及禽蛋中的兽药残留。通过对建模中所需的家禽的生理学及解剖学参数进行归纳总结,并对已有的家禽体内的生理药动学模型进行综述,同时分析了生理药动学模型在家禽体内应用的局限性。
Physiologically based pharmacokinetics（PBPK）model is a mathematical modeling technique for predicting the absorption,distribution,metabolism and excretion of chemical substances in animal species based on material balance principle. In veterinary medicine, the PBPK model has been used to study pharmacokinetics,tissue distribution and predict residue withdrawal time. At present,the researches of PBPK models are concentrated in pig,cattle,goat,sheep and dog,while there are few ones in poultry. The anatomical structures of poultry are very different from those of mammals. In addition, the composition of egg is very complex and the formation of egg is extremely complex. Therefore,it is difficult to predict drug residues in edible tissues and eggs based on PBPK model. In this paper,the physiological and anatomical parameters needed in poultry PBPK model were firstly summarized,then the literatures regarding the applicassion of PBPK model in poultry species were reviewed,and the limitations of PBPK model were finally analyzed.
出处
《中国家禽》
北大核心
2015年第9期42-45,共4页
China Poultry
基金
国家自然科学基金项目(31402253)
河南科技大学SRTP项目(2014267)
关键词
生理药动学模型
家禽
残留
预测
physiologically based pharmacokinetics model
poultry
residue
prediction
