摘要
[目的]探讨在短/超短降调节方案中使用口服避孕药预处理的作用.[方法]回顾性分析2008年8月至2009年1月在本院接受体外受精（IVF）或卵细胞浆单精子注射（ICSI）助孕的不孕症患者400例,控制性超排卵方案均为短/超短方案垂体降调节,短效避孕药处理组（A组）150例;未处理组（B组）250例.比较两组超排天数、血清激素水平、成熟（MⅡ）卵子数,受精率,优胚率,妊娠率.[结果]A组超排天数（9.26±1.74） d与B组（8.82±1.52） d比较有显著性差异（ P ＜0.05）;周期d2 两组卵泡刺激素（FSH）、黄体酮（P）比较有显著性差异（P＜0.05）;超排d4两组黄体生成素（ LH ）、 P比较有显著性差异（ P ＜0.05）;注射HCG日两组 LH、催乳素（PRL）比较有显著性差异（P〈0.05）;MⅡ卵子数、受精率、优胚率和妊娠率均无显著性差异（P〉0.05）.[结论]在控制性短/超短方案降调节中,使用短效避孕药进行预处理,对超排周期各时期的内分泌均有改变,延长了超排周期时间,促性腺激素（Gn）的用量没有差异.
[Objective] To investigate the role of oral contraceptive pill（OCP） pretreatment in short or supe-short protocol of downregulation of controlled ovarian hyperstimulation（COH）. [Methods] Totally 400 infertile patients receiving in-vitro fertilization（IVF） or intracytoplasmic sperm injection（ICSI） for the assisted reproduction in our hospital from Aug. 2008 to Jan. 2009 were analyzed retrospectively. Group A（ n = 150） received short-term OCP pretreatment in short or super-short protocol of downregulation of COH. Group B（ n =250） was not given pretreatment. The days of COH, serum levels of hormones, the number of mature o vum, the fertility rate, good-quality embryo rate and pregnancy rate were compared between two groups. [Results] The days of COH in Group A and group B were 9.26±1.74d and 8.82±1.52d, and there was significant difference between two groups （ P 〈0. 05）. In the d2-cycle, there was significant difference in follicle stimulating hormone（FSH） and progesterone（P） between two groups（ P 〈0.05）. At d4 of COH, there was significant difference in luteinizing hormone（LH） and P between two groups（ P 〈0.05）. At the day of human chorionic gonadotrophin（HCG） injection, there was significant difference in LH and prolactin（PRL） between two groups（ P 〈0.05）. However, there were no significant differences in the number of mature ovum, fertility rate, good-quality-embryo rate and pregnancy rate（ P 〉0. 05）. [Conclusion]The use of OCP pretreatment in short or super-short protocol of downregulation of COH can change the endocrine at each stage of COH cycle and prolong the duration of COH, but not alter the dosage of gonadotrophic hormone（Gn）.
出处
《医学临床研究》
CAS
2010年第11期2013-2015,共3页
Journal of Clinical Research
