摘要
目的:探讨粘附分子拼接变异体CD44v6在胃癌组织中的表达及其临床意义。方法:应用免疫组织化学SP方法检测了62例手术切除胃癌组织及15例正常胃粘膜组织中CD44v6的表达水平。结果:CD44v6蛋白在胃癌组织中阳性率为67.74%,正常胃粘膜组织无阳性表达;CD44v6表达与胃癌的侵入深度、临床分期、淋巴结转移和患者生存期在统计学上均差异显著(P<0.05),而与胃癌的组织学类型和组织学分级无关(P>0.05)。结论:CD44v6的表达与胃癌的发生、发展和预后等关系密切,可作为胃癌临床治疗和判断预后的参考指标。
Objective：To study the expression of human metastasis molecule adhesion CIM4 splice variant6 in gastric carcinoma and the relation to the clinicopathologieal features. Methods ： The expression of CD44v6 was detected with immunohistochemical SP method in 62 cases gast tic cancer and 15 normal gastric mucous tissue sample. Results：The positive expression rates of CDd-4v6 were 67. 74%, wasn＇t found in normal gast tic mucous tissues;CD44v6 protein expression was significandy correlated with invasion depth ,clinical term,lymph node metastasis and clinical pathological stage （P 〈 0. 05 ）, but was not related to histological type （ P 〉 0. 05 ）. Conclusion： The expression of CIM4v6 protein is correlated with gast He cancer and can be used to evaluate the biological behavior and prognosis of gast ric cancer.
出处
《黑龙江医药》
CAS
2010年第6期919-922,共4页
Heilongjiang Medicine journal
