摘要
利用三光气为酰化剂,芳胺在-5℃的条件下与单叔丁氧羰基保护的哌嗪反应,"一锅法"生成4-叔丁氧羰基哌嗪甲酰胺。然后在浓盐酸的二氧六环溶液中脱除叔丁氧羰基,得哌嗪甲酰胺衍生物。讨论了盐酸的用量对保护基脱除效率的影响。
N-Boc-Piperazinyl formamides were synthesized in ＂one-pot＂ procedure from aryl amines,triphosgene and N-boc-piperazine at-5℃.The protective group of boc was eliminated to give piperazinyl formamide derivatives in a solution of HCl in dioxane.The effect of the concentration of HCl was discussed.
出处
《精细化工中间体》
CAS
2010年第5期43-46,共4页
Fine Chemical Intermediates
