摘要
目的探讨血栓素A2(TXA2)和前列环素(PGI2)在胎儿生长受限发病中的作用。方法用放免法检测胎儿生长受限和正常妊娠各30例产妇母血脐血中TXB2和6-keto-PGF1α浓度,计算TXB2/6-ke-to-PGF1α比值。结果研究组母血脐血TXB2浓度明显增高,与对照组相比差异有显著性(P<0.01);研究6-keto-PGF1α浓度与对照组相比亦有所升高,但差异无显著性(P>0.05);研究组TXB2/6-keto-PGF1α明显高于对照组,差异有显著性(P<0.05)。结论母血脐血中TXA2浓度异常升高及TXA2/PGI2比例失衡与胎儿生长受限发病有关。
【Objective】To investigate the roles of thromboxane A2（TXA2） and prostaglandin I2（PGI2） in development of FGR.【Methods】The concentration of TXB2 and 6-keto-PGF1 in umbilical cord blood and pregnant blood collected from 30 normal parturients（control） and 30 parturients with FGR was detected by radioimmunoassay to calculate the TXA2/PGI2 ratio.【Results】Compared with the control group,the concentration of umbilical cord blood and pregnant blood TXB2 in FGR group was significantly increased（P0.01）,but the elevation of 6-keto-PGF1α concentration was not statistically significant（P 0.05）.The FGR group showed significantly higher positivity rates of TXB2 and 6-keto-PGF1 in than the control group（P0.01）.【Conclusion】Abnormal elevation of TXA2 con-centration in the umbilical cord blood and the TXA2/PGI2 imbalance are responsible for the development of FGR.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2010年第7期1042-1044,共3页
China Journal of Modern Medicine
基金
国家自然科学基金(No:30700669)
关键词
血栓素A2
前列环素
胎儿生长受限
母血
脐血
thromboxane A2
prostaglandin I2
fetal growth restrictions
umbilical cord blood
pregnant blood
