摘要
目的 探讨脑出血大鼠血清白蛋白水平与空肠黏膜形态学之间的关系.寻找导致低蛋白血症的机制.方法 制作脑出血大鼠模型.检测正常对照组、假手术组及脑出血组术后1、7、14 d（每组8只）血清白蛋白水平与空肠黏膜形态学的参数.进行血清白蛋白水平与空肠黏膜形态学的参数值之间的相关分析.结果 血清白蛋白与小肠绒毛高度（r=0.869,P＜0.01）、绒毛面积（r=0.659,P＜0.01）、黏膜厚度（r=0.915,P＜0.01）、肠腺深度（r=0.545,P＜0.05）及肠腺密度（r=0.475,P＜0.05）呈正相关.结论 血清白蛋白水平与空肠黏膜形态学变化的关系密切.
Objective To explore the correlation between the serum albumin level and the jejunal mucosal morphology in rats with cerebral hemorrhage and to find out the mechanism of the resulting hypoproteinemia.Methods A rat model of cerebral hemorrhage was used to detect the serum albumin level and the morphologic parameters of jejunal mucosa on day 1,7 and 14 after the hemorrhage.The results were compared to the normal control group and the sham-operated group. The correlation between the serum albumin level and the parameters of the jejunal mucosal morphology was explored.Results The serum albumin level was positively correlated with the small intestinal villous height（r =0.869,P〈0.01）,villous area（r=0.659,P〈0.01）,mucosal thickness （r=0.915,P〈0.01）,depth of intestinal glands（r=0.545,P〈0.05）and density of intestinal glands（r=0.475,P〈0.05）.Conclusion The serum albumin level is closely related to the morphologic changes of the jejunal mucosa.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2010年第11期801-804,共4页
Chinese Journal of Neurology
关键词
脑出血
血清白蛋白
肠黏膜
大鼠
Cerebral hemorrhage
Serum albumin
Intestinal mucosa
Rats
