摘要
目的探讨血小板α颗粒膜糖蛋白CD62P和溶酶体膜糖蛋白CD63的表达与急性脑梗死的关系。方法用流式细胞仪和单克隆抗体标记法检测61例急性脑梗死患者CD62P和CD63水平,并与59例正常对照组比较。结果急性脑梗死患者CD62P和CD63的表达明显高于正常对照组(6.26%±1.68%比2.32%±1.14%和6.14%±1.89%比2.88%±1.15%,P<0.01)。结论急性脑梗死患者血栓的形成与血小板的活化密切相关,且活化血小板的检测可以作为脑梗死早期诊断一项较特异的指标。
Aim To investigate the relationship between platelet CD62P and CD63 expression and acute cevebral infarction（ACI）. Methods The expression of CD62P,CD63 was detected by flow cytometry in 61 patients with acute cevebral infarction（ACI）,and 59 healthy control subjects. Results CD62P,CD63 in acute cevebral infarition were 6.26%±1.68% vs 2.32%±1.14%,6.14%±1.89% vs 2.88%±1.15% respectively,and the result has statistical significance compa with those of the control group（P〈0.01）. Conclusion The formation of thrombus in actute cerebral infaration patients is highly related to the platelets activation,which can be a diagnostic indicator of cevebral infarction disease.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2010年第9期744-745,共2页
Chinese Journal of Arteriosclerosis
关键词
急性脑梗死
活化血小板
流式细胞术
Acute Cevebral Infarction
Activated Platelets
Flow Cytometry
