摘要
目的观察西洛他唑对冠心病(CHD)合并2型糖尿病(2-DM)患者血小板聚集率(PAG)、血小板α颗粒膜糖蛋白(CD62p)和超敏C反应蛋白(hs-CRP)的影响,探讨各项指标的相关性及预后的关系。方法80例冠心病合并糖尿病患者随机分为两组,A组:阿司匹林0.1Qd;B组:阿司匹林0.1Qd+西洛他唑50mg,Bid;并设健康对照组。分别于入院第二天及用药1周后测定二磷酸腺苷(ADP)、花生四烯酸(AA)诱导的PAG变化,以及CD62p和hs-CRP水平。结果用药前A、B两组PAG(ADP、AA诱导)、CD62p及hs-CRP水平均高于对照组,两组之间无统计学差异;治疗1周后B组的PAG、CD62p及hs-CRP水平较A组显著降低,但CD62p及hs-CRP仍高于对照组。B组用药前后hs-CRP与ADP及AA诱导的PAG、CD62p呈正相关;B组6个月临床观察终点事件的发生率显著低于A组。结论西洛他唑可抑制合并2-DM冠心病患者PAG,降低CD62p及hs-CRP水平,改善预后。
Objective To study the effects of cilostazol on platelet aggregation rate （PAG）, platelet alpha -granular membrane protein （CD62p） and high sensitive C -recative protein （hs-CRP） in patients with coronary heart disease （CHD） and 2 - diabetes melhtus （2 - DM）, and observe the relationship between these indexes and prognosis. Methods 80 patients with CHD and 2 - DM were randomized in to two groups, group A： aspirin, group B： aspirin ＋ cilostazol. Group A received 100 mg of aspirin daily for 6 months without antiplatelet agent. Group B received 50 mg of cilostazol per twelve hours for 6 months besides aspirin. The heathly people were used as control group. The PAG induced by adenosine diphosphate （ADP） or arachidonic acid （AA）, CD62p and hs-CRP in blood samples were determined on second day and a week later. Results The PAG （induced by ADP or AA）, CD62p and hs-CRP in group A and group B were significantly higher than those in control group before therapy, and differences could not been found between groups A and B. After treatment for 1 week, the PAG, CD62p and hs-CRP of group B were significantly lower than those in group A, but CD62p and hs-CRP were higher than those in control group. The hs-CRP and PAG, the hs-CRP and CD62p in group B were positively related before and after therapy. The clinical accident of group B was lower than group A in six months. Conclusion Cilostazol can significantly decrease the PAG, CD62p and hs-CRP in patients with CHD and 2 - DM and improve the prognosis.
出处
《中国微循环》
2009年第1期42-45,共4页
Journal of Chinese Microcirculation
基金
河北省科学技术与社会发展指导性计划(072761441)
关键词
西洛他唑
冠心病
2型糖尿病
血小板聚集率
血小板α颗粒膜糖蛋白
超敏C反应蛋白
Cilostazol
Coronary heart disease （CHD）
2 -diabetes mellitus （2 -DM）
Platelet aggregationrate （PAG）
Platelet alpha - granular membrane protein （CD62p）
High sensitive C - reactive protein （hs-CRP）
