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Diagnosis and treatment of hypogonadism in older men: proceed with caution 被引量:4

Diagnosis and treatment of hypogonadism in older men: proceed with caution
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摘要 Male hypogonadism, defined as clinical features of androgen deficiency combined with confirmed unequivocally low testosterone levels [1], is a straightforward diagnosis in younger men with tmderlying testicular and pituitary pathology. The diagnosis ofhypogonadism in older men is challenging, because of the non-specificity of symptoms and the age-related decline in testosterone levels which is accelerated by chronic disease and obesity. Male hypogonadism, defined as clinical features of androgen deficiency combined with confirmed unequivocally low testosterone levels [1], is a straightforward diagnosis in younger men with tmderlying testicular and pituitary pathology. The diagnosis ofhypogonadism in older men is challenging, because of the non-specificity of symptoms and the age-related decline in testosterone levels which is accelerated by chronic disease and obesity.
机构地区 Department of Medicine
出处 《Asian Journal of Andrology》 SCIE CAS CSCD 2010年第6期783-786,共4页 亚洲男性学杂志(英文版)
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  • 1Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, et al;Task Force, Endocrine Society. Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2010; 95: 2536-59. 被引量:1
  • 2Wu FC, Tajar A, Beynon JM, Pye SR, Silman A J, et al; EMAS group. Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med 2010; 363: 123-35. 被引量:1
  • 3Basaria S, Coviello AD, Travison TG, Storer TW, Farwell WR, et al. Adverse events associated with testosterone administration. N Engl J Med 2010; 363: 109-22. 被引量:1
  • 4Fernandez-Balsells MM, Murad MH, Lane M, Lampropulos JF, Albuquerque F, et al. Clinical review 1: Adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis. J Clin Endocrinol Metab 2010; 95: 2560-75. 被引量:1
  • 5Srinivas-Shankar U, Roberts SA, Connolly MJ, O'Connell MD, Adams JE, et al. Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab 2010; 95: 639-50. 被引量:1

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