摘要
以香兰素和1,2-丙二醇为原料,对甲苯磺酸铜为催化剂,苯为带水剂,合成了香兰素1,2-丙二醇缩醛。考察了原料摩尔比、催化剂用量和反应时间等因素对产品收率的影响。结果表明:对甲苯磺酸铜具有良好的催化活性,且可重复使用3次。最佳工艺条件为:香兰素15.2 g(0.1 mol),n(香兰素):n(1,2-丙二醇)=1∶1.60,对甲苯磺酸铜0.9 g,苯25 mL,反应时间2.5 h条件下,产品收率达到87%以上。
Vanillin 1,2-propylene glycol acetal was synthesized from vanillin and 1,2-propylene glycol using copper p-toluene sulfonate as catalyst and benzene as water stripping agent.The effects of molar ratio of the reactants,catalyst dosage and reaction time on yield were investigated.Copper p-toluene sulfonate showed high catalytic activity,and the catalyst was reused for 3 times.The preferential conditions are： based on 15.2 g（0.1 mol） of vanillin,the molar ratio of vanillin to 1,2-propylene glycol is 1∶1.60;the dosage of catalyst is 0.9g,the amount of benzene as water stripping agent is 25 mL;the reaction time is 2.5 h.The yield can achieved 87%.
出处
《化学世界》
CAS
CSCD
北大核心
2010年第11期675-677,共3页
Chemical World
关键词
对甲苯磺酸铜
香兰素
香兰素1
2-丙二醇缩醛
合成
copper p-toluene sulfonate
vanillin
vanillin 1
2-propylene glycol acetal
synthesis
