摘要
脓毒症是严重创伤、烧伤、休克、大手术后常见的并发症,进一步发展可导致脓毒性休克和多器官功能障碍综合征,是临床危重病症中最常见的死亡原因。研究表明在脓毒症的病理生理过程中,涉及一系列复杂的整体反应,包括多种细胞因子、炎性递质和凝血系统的激活,这个过程的中心环节就是血管内皮细胞功能的改变。血管内皮细胞是参与炎症应答的主要靶细胞之一,同时近年来研究认为,血管内皮细胞不仅是炎症反应中被动的靶细胞,也是一种效应细胞,在微循环障碍、脓毒性休克及多器官功能损伤中起着重要作用。
Sepsis is a common complication after severe trauma,burning,shock,and major surgical operations.It can develop into sepsis shock and multiple organ dysfunction syndrome（MODS）and therefore is the most frequent cause of death among critically ill patients.A series of complicated responses are involved during the pathophysiological changes of sepsis,including the activation of many cytokines,inflammatory transmitters,and blood coagulation system.The change of vascular endothelial cell function plays a central role.The vascular endothelial cells are the main targets of inflammatory response.Recent studies have demonstrated that the vascular endothelial cells are not only the passive target cells during inflammatory response but effective cells,and therefore play a significant role in the microcirculation disturbance,sepsis shock,and MODS.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第32期3603-3606,共4页
Chinese General Practice
关键词
脓毒症
血管内皮细胞
研究
Sepsis
Vascular endothelial cells
Research
