摘要
目的探讨孟鲁司特纳对呼吸道合胞病毒毛细支气管炎患儿血清半胱氨酰白三烯(CysLTs)的影响并观察其疗效。方法选择年龄4～12个月的呼吸道合胞病毒毛细支气管炎患儿共100例,随机分为观察组和对照组各50例。对照组仅给予综合治疗,观察组在综合治疗的基础上加用孟鲁司特纳4mg每晚一次口服。于治疗前、后检测血清半胱氨酰白三烯(CysLTs)水平,并观察两组达到喘息缓解所需时间。结果观察组达到喘息缓解所需时间与对照组相比差异有统计学意义(P<0.05);同时观察组CysLTs水平较对照组显著下降(P<0.05)。结论孟鲁司特纳可缩短病程,降低呼吸道合胞病毒毛细支气管炎患儿CysLTs水平,在呼吸道合胞病毒毛细支气管炎的抗炎机制中起重要作用。
Objective To investigate the effect of montelukast sobium on the expression of cysteinylleukotrienes in infants with respiratory syncytial virus（RSV） bronchiolitis and the therapeutic actions. Methods 100 infants with RSV bronehiofitis（4 - 12 months） were randomly divided into 2 groups ：the trial group（ n = 50） and control group （n = 50）. The control group was given the routine therapy. Based on the routine therapy, the trial group was given montelukast sobium （4 mg qn）. The expression of eys- teinylleukotrienes before and after treatment and time taken for asthma to resolve were recorded. Results The time needed to settie the asthma in the trial group was statistically different that of the control group （P 〈 0.05 ）. The expression of cysteinylleukotrienes was also significantly lower than that of the control group （ P 〈 0.05 ）. Conclusion Montelukast sobium can shorten the course of disease, and lower the expression of cysteinylleukotrienes, and produce a marked anti-inflammatory effect in infants with RSV bronchiolitis.
出处
《中华全科医学》
2010年第12期1532-1533,共2页
Chinese Journal of General Practice
