摘要
目的:通过观察婴幼儿毛细支气管炎中T辅助细胞Th1/Th2细胞的功能变化,探讨其在毛细支气管炎中的意义。方法:采用ELISA方法测定毛细支气管炎、非喘息性肺炎患儿外周血中干扰素γ(IFN-γ)、白介素4(IL-4)、血清IgE的浓度。结果:(1)毛细支气管炎患儿IL-4的水平显著高于非喘息性肺炎患儿(M=1.66pg.mL-1,p5=0.05pg.mL-1,p95=35.46pg.mL-1)/(M=0.55pg.mL-1,p5=0.10,p95=21.71pg.mL-1)(P<0.05)。(2)IFN-γ在毛细支气管炎中的水平低于非喘息性肺炎,(M=5.93pg.mL-1,p5=0.59pg.mL-1,p95=278.93pg.mL-1)/(M=18.17pg.mL-1,p5=0.08pg.mL-1,p95=495.4pg.mL-1),差异有统计学意义(P<0.05)。(3)毛细支气管炎患儿IgE的浓度略高于非喘息性肺炎,(M=71.24,p5=2.35pg.mL-1,p95=867.13IU.mL-1)/M=19.58,p5=3.68pg.mL-1,p95=211.90IU.mL-1),但差异无统计学意义(P>0.05)。结论:婴幼儿毛细支气管炎中可能存在Th2优势反应。
Objective：To study the role of Th1/Th2 cell on bronchiolitis in infants.Methods：Totally 114 infants with pneumonia were enrolled and were radomly divided in two groups,bronchiolitis group and no-wheezing pneumonia group.The levels of IFN-γ,IL-4 and IgE were measured in two groups by ELISA.Results：（1） The infants with bronchiolitis had higher IL-4 levels than those of no-wheezingl pneumonia group,（M=1.66 pg·mL^-1,p5=0.05,p95=35.46 pg·mL^-1） /（M=0.55pg·mL^-1,p5=0.10,p95=21.71pg·mL^-1）（P〈0.05）（2） The levels of IFN-α in bronchiolitis group was lower than those of no-wheezing pneumonia group.The difference was significant.（M=5.93pg·mL^-1,p5=0.59,p95=278.93pg·mL^-1l） /（M=18.17pg·mL^-1,p5=0.08 p95=495.4 pg·mL^-1）（P〈0.05）.（3） Compared with no-wheezing pneumonia group,the IgE level of bronchiolitis group had no significant difference.（M=71.24,p5=2.35,p95=867.13IU·mL^-1） /M=19.58,p5=3.68,p95=211.90 IU·mL^-1）（P〉0.05）.Conclusion：The Th2 advantage may play a role in infant＇s bronchiolitis.
出处
《中国临床医学》
北大核心
2008年第3期335-336,共2页
Chinese Journal of Clinical Medicine
