摘要
目的：探讨酸碱双点电位法在有机弱酸弱碱性药物分析中的应用，并选择适宜的实验条件。方法：在１ ｍ ｏｌ／ Ｌ Ｋ Ｃｌ溶液中，分两次加入 Ｖ１ 和 Ｖ２ 体积 Ｈ Ｃｌ标准溶液，测定西咪替丁的含量，并与药典法对照。结果：在适宜的实验条件范围内，用酸碱双点电位法与药典法测定西咪替丁的含量结果相符合。结论：酸碱双点电位法具有简便、快速、准确等特点，在有机弱酸弱碱性药物分析中有一定的实用前景。
objective: The method discusses the application of the acid base double points potentiometric method in ana1ysing organic weak acid and base medicines, and selects appropriate experimental parameters. Methods: V 1 and V 2 vo1ume HCl standard solution were added in KCl l mol/L solution avoiding slow titration operation, then, contents of cimetidine were determined, and compared with pharmacopeial method. Results: Determination of the content of cimetidine by this method accords with the results of determination by pharmac0peial method within the range of appropriate experimental parameters. Conclusion: The acid base doub1e points potentiometric method is simple, rapid and precise, and has prospect of application in analysing organic weak acid and base medicines.
出处
《新疆医科大学学报》
CAS
1999年第1期50-51,共2页
Journal of Xinjiang Medical University
关键词
双点电位法
西咪替丁
含量
double points potentiometric method
cimetidine
assay
