摘要
目的了解医院抗菌药物应用与病原菌耐药现状,探讨抗菌药物用量与病原菌耐药性变迁之间的关系,指导临床合理用药。方法收集、统计对比分析2007-2008年住院部常用抗菌药物应用频度与病原菌的耐药率。结果 2年来,11种抗菌药物应用频度(DDDs)增长迅速,增长率>20.0%;送检标本阳性率55.9%,检出革兰阴性杆菌占56.5%,革兰阳性球菌占43.5%,主要分布于呼吸道、泌尿道、皮肤与组织;分离率排序前5位的病原菌分别是大肠埃希菌、肺炎克雷伯菌、金黄色葡萄球菌、鲍氏不动杆菌和铜绿假单胞菌,多药耐药菌株分离率及耐药率以不同程度逐年上升。结论加强临床抗菌药物应用管理与细菌耐药谱的监测,延缓及防止细菌耐药菌株的产生与传播。
OBJECTIVE To investigate the use of antibacterials and bacterial drug resistance and trendenly, to explore the relationship between antibacterial consumption and resistance rate of pathogenic bacteria to antibacterial drug in order to direct rational drug usage in the clinic. METHODS The DDDs of antibacterial drug and drug resistance rates of bacterials from 2007 to 2008 were collected and analyzed statistically in the inpatients. RESULTS The DDDs of 11 antibacterials showed great increase in the 2 years. The monitored results of bacteria showed that the detection-rate of pathogenic bacteria was 55.88% ,of which 56.39~ were Gram-negative bacilli, 13. 58% were Gram-positive cocci, and 28. 650./oo were fungi, which were mostly seen in respiratory tract, genitourinary tract and skin. Leading the first 5 places in the list of the isolated clinical pathogenic bacteria were Escherlchia coli ,Klebsiella pneumoniae ,Staphylococcus aureus ,Aclnetobacter baumannii and Pseudomonas aeroginosa. The isolated-rate and resistance rate of pathogens were increasing year by year in various degrees. CONCLUSION Strengthening the administration of the clinical antibacterial drug usage and the monitoring of the clinical bacteria resistance to delay the occurrence of bacteria resistance and preven bacteria resistance from being transmitted.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2010年第22期3563-3566,共4页
Chinese Journal of Nosocomiology
关键词
抗菌药物
应用频度
耐药率
合理用药
Antibacterials
DDDs
Drug resistance rate
Rational use
