摘要
目的:采用超声心动图评价2型糖尿病合并冠心病患者的左室结构和功能、左房结构和收缩功能。方法:50例2型糖尿病冠心病患者、26例单纯2型糖尿病患者及26例正常对照者,用超声心动图测定左室质量指数(LVMI)、二尖瓣舒张早期及晚期峰值血流速度(Em、Am)、二尖瓣环运动舒张早期及晚期峰值速度(Ea、Aa)左房容积指数(LAVmaxI和LAVminI)、左房灌注分数(LAFF)、左房射血力(LAEF)等指标。结果:与正常对照组相比,糖尿病组左室收缩功能指标无显著差异,但Em/Am及Ea/Aa显著降低(P<0.01),Em/Ea显著升高(P<0.05),LVMI和LAVmaxI显著增大(P<0.05),LAEF及LAFF显著增高(P<0.05和P<0.01)。与单纯糖尿病组相比,糖尿病冠心病组的LVMI和LAVmaxI(P<0.05)、LAEF及LAFF(P<0.01)进一步增高。结论:在左室收缩功能正常的糖尿病患者中,已经存在左室舒张功能降低、左房增大和左房收缩功能增强;糖尿病合并冠心病时左房结构及收缩功能异常进一步加重。
Objective：To assess left ventricular （LV） and left atrial （LA） structure and function using all currently available eehocardiographic methods in patients with type 2 diabetes mellitus combined with chronic coronary artery disease （CAD）. Methods：Three groups of patients were evaluated, including 50 patients with type 2 diabetes and chronic CAD, 26 type 2 diabetic patients without CAD, and 26 healthy control individuals. Echocardiography was performed and different M-mode, two-dimensional echocardiographic, pulse wave Doppler and tissue Doppler imaging parameters were quantitatively measured. Results：Compared to the control subjects, diabetic patients had a normal LV systolic function but significantly higher LVMI, Em/Ea, LAVmaxI, LAEF and LAFF （all P〈0.05）, and lower Era/Am and Ea/Aa （all P〈 0.01）. The diabetic patients with CAD had significantly higher LVMI, LAVmaxI （all P%005）, LAEF and LAFF （all P〈0.01）, when compared to those without CAD. Conclusion： LV diastolic dysfunction, IrA dilatation and enhanced LAEF existed already before the occurrence of significant LV systolic dysfunction in patients with type 2 diabetes mellitus. Patients with diabetes and CAD had more severe LA structural and functional abnormalities.
出处
《国际心血管病杂志》
2010年第6期367-370,共4页
International Journal of Cardiovascular Disease
关键词
超声心动图
组织多普勒成像
糖尿病
左室功能
左房功能
Echocardiography
Tissue Doppler imaging
Diabetes mellitus
Left ventricular function
Left atrial function
