摘要
目的:探讨宫颈上皮内瘤变(CIN)治疗前后人乳头状瘤病毒(HPV)载量与预后的意义。方法:从2006年6月～2009年9月间在新疆维吾尔自治区人民医院妇科门诊和妇科病房就诊的190例CIN患者,经宫颈环形电切术(LEEP)或宫颈冷刀锥切术治疗后进行1年随访,检测治疗前后HPV的载量,对病灶持续存在和复发进行分析。结果:CIN患者经LEEP或宫颈冷刀锥切术治疗后HPV平均载量较治疗前均显著降低(P<0.01)。随着HPV病毒载量持续时间越长,病变的持续存在率、复发率越高。结论:LEEP或宫颈冷刀锥切能显著降低CIN患者HPV载量,病毒载量影响疾病预后,其研究对随访和预后都有指导意义。
Objective： To evaluate human papilloma virus （HPV） load and prognostic significance before and after treatment of cervical intraepithelial neoplasia （CIN）. Methods： 190 CIN patients were selected between June 2006 ～ September 2009 from the gyne-cology clinic and gynecological ward of Xinjiang Uygur Autonomous Region People＇s Hospital. All the patients were treated with the cervical loop electrosurgical excision procedure （LEEP） or cervical cold knife conization with follow-up for one year after treatment. HPV load were tested before and after treatment, and the persistence and recurrence of lesions were analyzed. Results： The average HPV load of CIN patients were significantly decreased after treatment of LEEP or cervical cold knife conization （P 〈0.01）. The longer the duration of HPV viral load, the higher the persistence rate and recurrence rate of disease. Conclusions： LEEP or cervical cold knife conization can significantly reduce the HPV viral load of CIN patients. Research and test of HPV viral load could be conducive to the disease prognosis and follow-up.
出处
《现代生物医学进展》
CAS
2010年第20期3903-3904,3891,共3页
Progress in Modern Biomedicine
关键词
宫颈上皮内瘤变
治疗前后
人乳头状瘤病毒载量
Cervical intraepithelial neoplasia（CIN）； Before and after treatment； Human papilloma virus load；
