宫颈上皮内瘤变治疗前后人乳头状瘤病毒负荷与疾病预后的关系被引量：9

下载PDF

导出

摘要目的:探讨宫颈上皮内瘤变(CIN)治疗前后人乳头状瘤病毒(HPV)负荷与疾病预后的关系。方法:对202例CIN患者经宫颈环形电切术(LEEP)或宫颈冷刀锥切术治疗后进行3～5年随访,检测治疗前后HPV-DNA的负荷量,对病灶持续存在和复发等情况进行分析总结。结果:CIN患者经LEEP或宫颈冷刀锥切术治疗后HPV-DNA平均负荷量较治疗前均显著降低(均P<0.01)。随着CIN级别的升高,病毒负荷量越高,病变的持续存在率、复发率越高。结论:LEEP或宫颈冷刀锥切能显著降低CIN患者HPV-DNA负荷量,病毒负荷量影响疾病预后。

作者胡海燕徐瑾

机构地区南方医科大学附属深圳妇幼保健院

出处《实用医学杂志》 CAS 2008年第2期199-200,共2页 The Journal of Practical Medicine

关键词宫颈上皮内瘤样病变乳头状瘤病毒人外科手术病毒负荷

分类号 R737.33 [医药卫生—肿瘤] R318.14 [医药卫生—临床医学]

引文网络
相关文献

参考文献7

1Munoz N, Bosch F X, de Sanjose S, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer [J]. N Engl J Med, 2003,348(6):518-527. 被引量：1
2Nygard J F, Sauer T, Skjeldstad F E, et al. CIN2/3 and cervical cancer after an ASCUS pap smear. A 7-year, prospective study of the Norweigian population-based, coodinated screening program [J]. Acta Cytol, 2003,47(6) :991-1000. 被引量：1
3Khunnamompong S, Raungrongongmorakot K, Siriaukgul S. Loop electosurgical excision procedure(LEEP) at Maharaj Nakon Chiang Mai Hospital;problems in pathologic evaluation [J]. J Med Assoc Tai, 2001,84(4) :507-514. 被引量：1
4徐一红.宫颈电环切除术治疗宫颈上皮内瘤变93例[J].实用医学杂志,2007,23(6):868-870. 被引量：9
5谭毅,李淑玲,谢平,林婷.高危型人乳头瘤病毒联合细胞学检测原发和复发重度宫颈上皮内瘤变[J].实用医学杂志,2006,22(6):672-673. 被引量：13
6Dalstein V, Riechmuller D, Pretet J L, et al. Persistence and load of high risk HPV are predictors for development of high grade cervical leisions:a longitudinal French cohort study [J]. Int J Cancer, 2003,106(3) :396-403. 被引量：1
7Moberg M, Gustavsson I, Wilander E, et al. High viral loads of human papillomavirus predict risk of invasive cervical carcinoma [J]. Br Cancer, 2005,92(5) :891-894. 被引量：1

二级参考文献16

1杨斌,王爱民,黎雯.宫颈病变与人类乳头瘤病毒的研究进展[J].国外医学（皮肤性病学分册）,2005,31(3):151-153. 被引量：12
2曾华彬.高频电波刀在宫颈病变的应用[J].福建医科大学学报,2005,39(4):476-478. 被引量：6
3邬素芳,易诚青,徐茜,王薇,辜海念,卢运萍,马丁.杂交捕获二代法检测高危型人乳头瘤病毒DNA的意义[J].中国实用妇科与产科杂志,2006,22(3):181-183. 被引量：15
4谭毅,李淑玲,谢平,林婷.高危型人乳头瘤病毒联合细胞学检测原发和复发重度宫颈上皮内瘤变[J].实用医学杂志,2006,22(6):672-673. 被引量：13
5HO G Y,KADISH A S,BURK R D,et al.HPV16 and cigarette smoking as risk factors for high grade cervical intraepithelial neoplasia[J].Int Cancer,1998,78(3):281-285. 被引量：1
6HO G Y,KADISH A S,BURK R D,et al.HPV16 and cigarette smoking as risk factors for high grade cervical intraepithelial neoplasia[J].Int Cancer,1998,78(3):281-285.16:11 2006-5-30 被引量：1
7ZIELINSKI G D,ROZENDAAL L,VOORHORST F J,et al.HPV testing can reduce the number of follow up visits in women treated for cervical intraepithelial neoplasia grade 3[J].Gynecol Oncol,2003,91(1):67-73. 被引量：1
8COSTA S,DE SIMONE P,VENTUROLI S,et al.Factors predicting human papillomavirus clearance in cervical intraepithelial neoplasia lesions treated by conization[J].Gynecol Oncol,2003,90(2):358-365. 被引量：1
9BELINSON J,QIAO Y L,PRETORIUS R,et al.Shanxi Province Cervical Cancer Screening Study:a cross sectional comparative trial of multiple techniques to detect cervical neoplasia[J].Gynecol Oncol,2001,83(2):439-444. 被引量：1
10SCHIFFMAN M,HERRERO R,HIDESHEIM A,et al.HPV DNA testing in cervical cancer screening:results from women in a high risk province of Costa Rica[J].JAMA,2000,283(1):87-93. 被引量：1