摘要
喜树碱(CPT)是一种具有良好抗癌性能的植物性抗癌药.由于其水溶性较差,在临床上的应用受到一定的限制,因此以自制的苄基–聚乙二醇–g–聚天冬氨酸为载体,采用溶剂挥发法制备喜树碱载药胶束.结果表明,两亲性接枝聚天冬氨酸胶束对抗癌药物喜树碱具有一定的载药能力,并具有良好的水溶性,其体外释药曲线符合FickⅡ扩散动力学模型.
Camptothecin（CPT）,a plant alkaloid,was found as a new type of antitumor agent with pharmacologically effec-tion.However,CPT’s extremely insolubility severely restrick its clinical applications.So new type of amphiphilic grafted polyaspartic acid was applied as carrier to encapsulate CPT by solvent evaporation method.It shows that the prepared mi-celles can be used as carriers of CPT and has good water solubility,the drug-loading micelles released drug in PBS under the rule of FickⅡdiffusion model.
出处
《天津科技大学学报》
CAS
2010年第5期6-9,共4页
Journal of Tianjin University of Science & Technology
基金
天津科技大学引进人才科研启动基金资助项目(20090404)
关键词
接枝聚天冬氨酸
胶束
喜树碱
控制释放
grafted polyaspartic acid
micelles
camptothecin（CPT）
controlled release
