摘要
采用Ｖ－Ｃ扩散池及小鼠皮肤建立的透皮模型和紫外可见分光光度法，考察了不同ｐＨ值及其条件下氮酮（Ａｚｏｎｅ）对大黄提取物中大黄酚透皮吸收的影响。结果表明：大黄酚在酸性介质中的透皮效果最佳，且Ａｚｏｎｅ对其透皮吸收有显著增强作用。
Effects of pH and azone on the transdermal absorption of chrysophanic acid by mouse skin were studied in vitro by Valian--Chien horizontal diffusion cell and UV spectrometry. Result of the study showed that maximum absorption was attained at pH4 and that azone is an excellent transdermal penetrant to enhance absorption.
出处
《中草药》
CAS
CSCD
北大核心
1999年第5期358-359,共2页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金!39360084
江西省自然科学基金
关键词
大黄酚
氮酮
PH值
透皮吸收
Azone
transdermal absorption
chrysophanic acid
