摘要
用Ｖ－Ｃ双隔室皮肤渗透池测定川乌生物碱在不同ｐＨ值（４．０、７．０、９．０）的缓冲液溶剂中透过为体鼠皮的情况以及透皮促进剂氮酮（Ａｚｏｎｅ）对该溶剂中药物的促渗效果。结果，川乌生物碱在ｐＨ４．０的溶液体系中渗透系数最大；加入Ａｚｏｎｅ有极显著性透皮增强作用。
We made the research of effects of R,aconniti to penetrate into the skin ofmouse in buffer soulutions of different pH4.0、7.0 and 9.0,respectely and a sorption promot-er(Azone)on the ability of the drug to promot into the skin,by determining its total alka-loids in Vilia-Chien(V-C)Skin Permeation Cell.The result of the study indicates that the largest coefficient of absorption is in the pH4-solution and that Azone has obvious ability of enhancing penetratation.
出处
《江西中医学院学报》
1994年第4期28-30,共3页
Journal of Jiangxi College of Traditional Chinese Medicine
基金
国家自然科学基金
江西省自然科学基金
关键词
川乌
生物碱
PH值
氮酮
透皮吸收
Radix conniti
Alkaloid
pH value
Azone
Peroutaneous absorption
