摘要
目的:探讨黏液表皮样癌(mucoepidermoid carcinoma,MEC)中表皮生长因子受体4(human epi-dermal growth factor receptor4,HER4)的表达及与MEC临床病理因素的关系。方法:采用SP免疫组化方法检测45例黏液表皮样癌和15例正常涎腺组织中HER4的表达。结果:HER4表达主要定位于肿瘤细胞的胞浆,当着色强时,通常可见完整或不完整的胞膜着色。MEC阳性表达31例(69%),阴性表达14例(31%)。HER4的表达与性别、年龄、部位、肿瘤直径、临床症状、淋巴结转移、临床分期无关(P>0.05),而与组织学分级呈明显负相关(P<0.05)。结论:HER4的表达与MEC组织学分级呈负相关;ErbB4癌基因可能参与MEC的发生与发展,需积累更多的资料研究,以明确其生物学作用。
Objective：To assess the expression of HER4 in mucoepidermoid carcinoma of salivary gland origin,and its correlation to clinicopathologic factors of mucoepidermoid carcinoma.Methods：A total of 45 cases of mucoepidermoid carcinoma and 15 normal salivary gland tissues were examined using a standard streptavidinbiotin method.Results：Immunostaining was observed predominantly in the cytoplasm.When cytoplasmic staining was strong,a partial or complete circumferential membrane pattern of immunostaining could be seen.A total of 31 cases（69%）showed positivity and 14 cases（31%）were negative.There was no association between the expression of HER4 with age,sex,tumor site,tumor size,nodal metastasis,and clinical stage（P〉0.05）,but significant adverse association between the expression of HER4 with histological grade was noted（P〈0.05）.Conclusions：HER4 receptor protein has high negative correlation with histological grade in MEC,and maybe play a certain role in initiatation and developing of salivary MEC.Further studies are required to elucidate the biological behavior of HER4 in MEC.
出处
《海南医学院学报》
CAS
2010年第9期1114-1116,1123,共4页
Journal of Hainan Medical University
基金
海南省自然科学基金资助项目(309038)~~
