摘要
目的:研究HER4在结肠癌中的表达并探讨其临床意义。方法:选择47例经哈尔滨医科大学附属肿瘤医院病理科确诊的结肠癌术后蜡块标本重新切片,经HE染色并由该院病理科医生重新阅片确诊;另取6例术后经病理检查证实为非恶性的结肠组织(视为良性结肠组织)作为对照,应用免疫组织化学方法(SP法)检测HER4在结肠癌各组癌组织及正常结肠组织中的表达和分布情况。结果:HER4在结肠癌组织及良性结肠组织中均有表达,但在良性结肠组织中呈非过度表达,而在结肠癌组织中呈过度表达(P=0.023)。HER4在Dukes分期为A期的结肠癌组织中均呈非过度表达,B期过度表达率为35.71%,C期过度表达率为75.00%,D期过度表达率为80.00%,存在统计学差异(P=0.028)。有淋巴结转移的结肠癌组织中过度表达率为75.00%,而无淋巴结转移的结肠癌组织中过度表达率为35.48%,结果存在统计学差异(P=0.010)。结论:HER4在结肠癌组织中的过度表达明显增强,并且与结肠癌的临床分期密切相关,临床分期较晚的患者HER4过度表达较高。HER4在结肠癌组织中的过度表达预示着肿瘤的恶性程度更高,生物攻击行为更强,发生潜在转移的可能性更大。
Objective:To investigate the expressinn of HER4 in colon carcinoma and the possible significance. Methods:The specimens were taken from 47 colon carcinoma tissues and 6 normal colon tissues from the affiliated tumour hospital of Harbin medical university.SP immunohistochemistry was used to evaluate the expression of HER4 in 47 colon carecnoma tissues and 6 normal colon tissues. Results:HER4 is expressed both in colon carcinoma tissues and normal colon tissues,but there is no overexpression of HER4 in normal colon tissues,and the overexpression rate of HER4 in colon carcinoma was 48.94%(P=0.023). The overexpression rate of HER4 was seen in 0%(0/2)Dukes stage A cases,35.71%(10/28)stage B cases,75.00%(9/12)stage C cases and 80.00%(4/5) stage D cases(P=0.028).12 of 16(75.00%)cases with metastasis of lymphnode have overexpression expression of HER4,while only 11 of 31(35.48%)cases without metastasis of lymph node(P=0.010). Conclusions:The overexpression of HER4 is elevated in colon carcinoma,and its overexpression is significantly associated with clinical stage. HER-4 overexpression status may prognosticate colon carcinoma with more malignant level,more aggressive biological behavior and more increased metastatic potential.
出处
《黑龙江医药》
CAS
2014年第3期546-548,549,共4页
Heilongjiang Medicine journal
