摘要
目的探讨HLA-DQ/DP等位基因与粤籍汉族斑秃及中医证型的相关性。方法采用聚合酶链反应-序列特异性引物(PCR-SSP)分型技术,对51例粤籍汉族斑秃患者的HLA-DQ/DP等位基因进行检测,并与110名粤籍汉族健康人群进行对照。结果 HLA-DQA1*0201、DQA1*0601、DQB1*0501、DQB1*0602、DPA1*0103基因频率斑秃组显著高于对照组,有极显著性差异(P<0.05或P<0.01);DQB1*0301、DPA1*0201基因频率斑秃组显著低于对照组(P<0.05);DQA1*0301气血两虚证基因频率显著高于其他证型(P<0.05)。结论 HLA-DQA1*0201、DQA1*0601、DQB1*0501、DQB1*0602、DPA1*0103可能是斑秃的易感基因,DQB1*0301、DPA1*0201可能是斑秃的保护基因,DQB1*0301主要与重型组有关,DQB1*0501、DPA1*0103则与轻型组相关,DQA1*0301可能是气血两虚证的易感基础。
Objective To identify the HLA-DQ/DP alleles associated with alopecia areata（AA）and the sub-types differentiated based on traditional Chinese medicine（TCM）theory in Chinese Han people of Yue region.Methods HLADQ/DP alleles of 51 alopecia areata patients were detected by polymerase chain reaction sequence specific primer（PCRSSP）,under the comparison with 110 healthy persons of Yue region.Results The frequence of HLA-DQA1＊0201,DQA1＊0601,DQB1＊0501,DQB1＊0602,DPA1＊0103 alleles increased obviously in alopecia areata group compared with control group（P0.05 or P0.01）.The frequence of DQB1＊0301,DPA1＊0201 alleles decreased in alopecia areata group compared with control group（P0.05）.The frequence of DQA1＊0301 from the patient with the sub-type＂Qixue-Buzu＂was much higher than that of other sub-types（P0.05）.Conclusion HLA-DQA1＊0201,DQA1＊0601,DQB1＊0501,DQB1＊0602,DPA1＊0103 alleles might be predisposing genes for alopecia areata in Han people of Yue region,and DQB1＊0301,DPA1＊0201 alleles might be protective genes from alopecia areata.DQB1＊0301 might be related to the dangerous group,and DQB1＊0501,DPA1＊0103 might be related to the lighe illness group.DQA1＊0301 might be predisposing genes for the subtype＂Qixue-Buzu＂of alopecia areata.
出处
《中国中西医结合皮肤性病学杂志》
CAS
2010年第5期289-292,共4页
Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine
