摘要
目的：探讨伴有破骨细胞样巨细胞的胰腺未分化癌的临床病理特点.方法：观察1例伴有破骨细胞样巨细胞的胰腺未分化癌的形态学特征,并进行免疫组织化学染色.结果：伴有破骨细胞样巨细胞的胰腺未分化癌肿瘤主要有两种细胞组成,一种为单核细胞,分为组织细胞样单核细胞和梭形或多形性瘤细胞两型;另一种为多核巨细胞,分为非肿瘤性的破骨细胞样巨细胞和瘤巨细胞两型.免疫组织化学研究显示,这两种细胞Vimentin均阳性,均不表达cytokeratin（AE1/AE3）,CK5/6,CEA,CgA;其中破骨细胞样巨细胞、组织细胞样单核细胞CD45,CD68阳性,而瘤巨细胞和梭形瘤细胞阴性.结论：伴有破骨细胞样巨细胞的胰腺未分化癌是一种罕见恶性肿瘤,可能为胰腺未分化癌的一个亚型.诊断需与胰腺恶性纤维组织细胞瘤、转移的骨巨细胞瘤或黑色素瘤等鉴别.
Objective：To investigate the clinicopathological features of undifferentiated carcinoma with osteoclast - like giant cells of pancreas. Methods：A case of undifferentiated carcinolna with osteoclast, like giant cells of pancreas was analyzed by light microscopy and studied by immunohistochemistry. Results ： The tumor was mainly composed of two kinds of the cells： one was mononuclear cells, the other was muhinuclear cells. And the former were divided into two types of cells ： histiocytoid mononuclear cells and spindle or polygon cells, the latter consisted of non - tumorous osteoelast - like giant cells and giant tumor cell. Both types showed immunohistochemically positive to vimentin, but negative to cytokeratin （AEI/AE3） , CK5/6, CEA and chromogranin. The majority of osteoelast - like giant cells and histiocytoid mononuclear cells showed positive to CD68 and CD45,while the spindle and polygon cells were negative. Conclusions：Undifferentiated carcinoma with osteoclast - like giant cells of pancreas is a rare malignant tumor, which might be a new subtype of undifferentiated carcinoma of pancreas, and should be differentiated from malignant fibrous histiocytoma of the pancreas and the transfer of giant cell tumor of bone or melanoma.
出处
《解剖与临床》
2010年第5期341-343,347,共4页
Anatomy and Clinics
关键词
胰腺肿瘤
未分化癌
破骨细胞样巨细胞
Pancreatic tumor
Undifferentiated carcinoma
Osteoclastic giant cells
