摘要
目的探讨在老年慢性心衰患者及心源性恶病质患者中肿瘤坏死因子-α(TNF-α),白细胞介素-6(IL-6)的变化及临床意义。方法以71例老年慢性心衰患者(包括30例心源性恶病质患者)和20例无心衰老年对照组为研究对象,采用放射免疫法测定血清TNF-α和IL-6的浓度,用心脏超声测定左室射血分数(LVEF)。结果 TNF-α和IL-6的浓度在各组均有升高,41例老年心衰患者心功能Ⅲ级、Ⅳ级组中TNF-α和IL-6明显高于对照组(P<0.05),30例老年心源性恶病质患者各组中TNF-α和IL-6升高显著(P<0.01)。在相关性分析中,TNF-α、IL-6与LVEF呈高度负相关,随心衰程度加重,LVEF越低,TNF-α和IL-6浓度越高。而TNF-α和IL-6在心衰和心源性恶病质各观察组中均同时增高,两者呈正相关。结论无论是老年心衰患者还是老年心源性恶病质患者,TNF-α和IL-6可反映心衰程度,均有一定的临床意义。
Objective To investigate the changes and clinical significance of tumor necrosis factor-α（TNF-α）and interleukin-6（IL-6）in elderly patients with chronic heart failure（CHF）and cardiac cachexia.Methods 71 elderly patients with CHF（including 30 cases of patients with cardiac cachexia）and 20 cases without CHF control group subjects.Measured by radioimmunoassary of serum TNF-α and IL-6 concentration.To measure left ventricular ejection fraction（LVEF）with echocardiography.Results TNF-α and IL-6 concentrations are higher in each group,41 cases of senile cardiac function in patients with heart failure grade Ⅲ,Ⅳ-level group,TNF-α and IL-6 is significantly higher（P〈0.05）,30 elderly patients with cardiac cachexia in TNF-α and IL-6 in each group increased significantly（P〈0.01）.In correlation analysis,TNF-α and IL-6 is highly negatively correlated with LVEF,increased levels decline blossoms,LVEF lower.TNF-α and IL-6 levels higher.The TNF-α and IL-6 in congestive heart failure and cardiac cachexia in the observation group are also increased,a positive correlation between.Conclusion Whether elderly patients with heart failure or with cardiac cachexia,TNF-α and IL-6 may reflect the degree of heart failure,and have some clinical significance.
出处
《中国老年保健医学》
2010年第5期19-20,共2页
Chinese Journal of Geriatric Care
