摘要
目的探讨肠内营养对老年肺源性心脏病(肺心病)心力衰竭(心衰)及肺心病合并心源性恶病质患者心功能及血清炎性因子的影响。方法以71例老年肺心病心衰患者为研究对象,其中包括30例肺心病合并心源性恶病质患者。将患者随机分为2组,2组在常规治疗心衰同时,A组自由饮食,B组给予肠内营养。治疗前后均检测各营养指标,用放免法测肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6),用心脏超声检测左室射血分数(LVEF)。结果 A组中,治疗后各营养指标改善不大,血清炎性因子水平及心功能有所改善,但治疗前后比较差异无统计学意义(P>0.05)。B组患者在治疗后各营养指标均有改善,炎性因子水平均有降低,心功能均有所改善,治疗前后比较差异有统计学意义(P<0.05),尤其在心源性恶病质患者中改善更为明显(P<0.01)。结论老年肺心病心衰及合并心源性恶病质患者,在常规治疗心衰的同时重视肠内营养治疗,可以改善患者营养状况从而改善免疫功能,调节炎性因子水平,进一步改善患者心功能。
Objective To investigate the effects of enteral nutrition on cardiac function and serum inflammatory factors in elderly patients with chronic pulmonary heart failure and cardiac cachexia. Methods Seventy-one elderly patients with chronic pulmonary heart failure, including 30 cases of cardiac cachexia,were enrolled in this study.The patients were randomly divided into two groups. Both groups received conventional treatment for heart failure, and at the same time one group received enteral nutrition, another group receiving free diet. Before and after treatment the levels of nutritional index, tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), and left ventricular ejection fraction were detected. Results The nutritonal index, TNF-α, IL-6, and left ventricular ejection fraction were significantly improved after enteral nutrition (P<0.05),particularly in patients with cardiac cachexia (P<0.01). While there was no significant improvement in free diet group (P> 0.05). Conclusions Enternal nutrition on the basis of conventional treatent for heart failure could improve the immue function, regulate the levels of inflammatory factors, and improve the carciac function in the elderly patients with chronic pulmonary heart failure and cardiac cachexia.
出处
《实用老年医学》
CAS
2013年第4期315-317,320,共4页
Practical Geriatrics
