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沙利度胺+FOLFIRI方案化疗对晚期结直肠癌患者VEGF及TNF-α的影响 被引量:1

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摘要 目的探讨沙利度胺+FOLFIRI方案化疗对晚期结直肠癌患者血管内皮生长因子(VEGF)及TNF-α的影响。方法将46例结直肠癌患者随机分为两组,治疗组用沙利度胺+FOLFIRI方案化疗,对照组用FOLFIRI方案化疗,治疗4周期后观察临床疗效;治疗前后用ELISA法检测其外周血VEGF、TNF-α。结果治疗组缓解率39.1%,对照组30.4%,两组比较无统计学差异。与对照组比较,治疗组治疗后VEGF、TNF-α明显降低(P<0.05)。结论沙利度胺+FOLFIRI方案化疗可明显降低晚期结直肠癌患者的VEGF、TNF-α。
出处 《山东医药》 CAS 北大核心 2010年第37期73-74,共2页 Shandong Medical Journal
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