摘要
目的:探讨甲状腺胸腺样分化癌(CASTLE)的临床病理特征和鉴别诊断。方法:对1例甲状腺CAS-TLE进行光镜观察及免疫组化检测,并结合临床及病理特点进行分析。结果:肿瘤发生于甲状腺下极,不规则形,与周围界限较清,切面灰白色。临床上主要表现为甲状腺无痛性包块,活动度差,伴呼吸困难。其组织学特点为肿瘤细胞较大,多边形、卵圆形,细胞核泡状,核仁明显,肿瘤细胞呈片状、索条状、岛状,间质可见纤维组织及成熟的淋巴细胞和浆细胞。免疫组织化学,肿瘤细胞表达CD5、CD117和CK。结论:甲状腺CASTIE是一种少见的甲状腺恶性肿瘤,具有一定的病理学特征,其诊断与鉴别诊断有赖于组织病理学及免疫组化检测,手术广泛全切是本病的主要治疗措施。
Objective：To investigate the clinicopathological features of carcinoma showing thymus-like differentiation（CASTLE） of thyroid and its diferential diagnosis.Methods： The clinical and pathological characteristics were studied by hematoxylin and eosin stain and immunohistochemical techniques in 1 case of carcinoma showing thymus-like differentiation of the thyroid.Results： The irregular tumor was located at inferior pole of the thyroid.It was well-demarcated and appeared grayish-white on cut surface.The major clinical manifestations were fixed movement and painless mass at thyroid and dyspnea.Microscopically,the large tumor cells were polygonal or oval shape with vesicular karyon and distinct nucleoli,the tumor cells were arranged in sheets,strips and islands,mature lymphocytes,plasma cells and fibrous tissues in the stroma.Immunohistochemi cally,the tumor was positive for CD5,CD117 and CK.Conclusion： CASTLE is a rare type of thyroid carcinoma with distinctive morphologic features.The diagnosis depends on the histology and Immunohistochemistry.It＇s main treatment is complete resection
出处
《现代肿瘤医学》
CAS
2010年第10期1935-1938,共4页
Journal of Modern Oncology
关键词
甲状腺肿瘤
癌
临床病理
thyroid neoplasms
cancer
clinical pathological
